近视儿童接受角膜矫形术后反应不佳者接受低强度红光联合疗法后轴长缩短的情况

IF 1.8 4区 医学 Q3 OPHTHALMOLOGY
Journal of Ophthalmology Pub Date : 2024-08-10 eCollection Date: 2024-01-01 DOI:10.1155/2024/4133686
Mengting Yu, Xianghua Tang, Jinyun Jiang, Fengqi Zhou, Lili Wang, Chuqi Xiang, Yin Hu, Xiao Yang
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引用次数: 0

摘要

目的:研究正角膜塑形镜(ortho-k)和重复低强度红光(RLRL)疗法治疗近视儿童正角膜塑形镜不良反应者的有效性和安全性:研究对象是在一项回顾性研究中完成两年角膜矫形治疗的 100 名近视儿童。在接受角膜矫形治疗的第一年(第一阶段),他们的轴向伸长率达到或超过 0.30 毫米(定义为角膜矫形反应不良者)。孩子们被分为两组:角膜矫形组(OK,n = 45)继续接受角膜矫形单药治疗,联合组(OK-RLRL,n = 55)在接下来的一年里(第二阶段)除了接受角膜矫形治疗外,还接受 RLRL 治疗。结果:OK 组和 OK-RLRL 组在第一阶段的平均年龄、男女比例、轴向长度(AL)和轴向伸长率相当(P 均大于 0.05)。在第二阶段,与 OK 组儿童相比,OK-RLRL 组的 AL 明显缩短(-0.10 ± 0.16 mm vs 0.30 ± 0.19 mm,P < 0.001)。在OK-RLRL组的55名近视儿童中,有35人(63.6%)、25人(45.4%)、11人(20%)、6人(10.9%)和3人(5.4%)的AL缩短率分别超过0.05毫米/年、0.10毫米/年和0.20毫米/年、0.3毫米/年和0.4毫米/年。基线年龄越大(β = -0.02)、治疗依从性越高(β = -0.462)、1 个月时的 AL 变化越小(β = 1.263)(所有 P 均小于 0.05):结论:对于角膜矫形反应不佳者,RLRL 除了能减缓角膜矫形治疗效果外,还能减缓轴向伸长。随着年龄的增长,对角膜矫形术反应差的人可能会从联合疗法中获益更多。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Axial Length Shortening after Combined Repeated Low-Level Red-Light Therapy in Poor Responders of Orthokeratology in Myopic Children.

Purpose: To investigate the efficacy and safety of orthokeratology (ortho-k) and repeated low-level red-light (RLRL) therapy in treating poor responders of ortho-k in myopic children.

Methods: Study participants were 100 myopic children who completed two years of ortho-k treatment in a retrospective study. In the first year of ortho-k treatment (phase one), they experienced axial elongation of 0.30 mm or greater (defined as poor responders to ortho-k). Children were divided into two groups: the orthokeratology group (OK, n = 45) continued to receive ortho-k monotherapy and the combination group (OK-RLRL, n = 55) received RLRL in addition to ortho-k for the next year (phase two). Axial elongation over time between the groups was compared.

Results: The mean age, male-to-female ratio, axial length (AL), and axial elongation in phase one were comparable between OK and OK-RLRL groups (all P > 0.05). During phase two, significant AL shortening was observed in the OK-RLRL group compared with children in the OK group (-0.10 ± 0.16 mm vs 0.30 ± 0.19 mm, P < 0.001). Among these 55 myopic children in the OK-RLRL group, 35 (63.6%), 25 (45.4%), 11 (20%), 6 (10.9%), and 3 (5.4%) of them had AL shortening over 0.05 mm/year, 0.10 mm/year, and 0.20 mm/year, 0.3 mm/year, and 0.4 mm/year, respectively. Older baseline age (β = -0.02), higher treatment compliance (β = -0.462), and AL change at 1 month (β = 1.263) were significantly associated with less AL elongation (all P < 0.05).

Conclusions: For poor responders of orthokeratology, RLRL could slow axial elongation in addition to the ortho-k treatment effect. Those who respond poorly to ortho-k with elder age might benefit more from combined therapy.

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来源期刊
Journal of Ophthalmology
Journal of Ophthalmology MEDICINE, RESEARCH & EXPERIMENTAL-OPHTHALMOLOGY
CiteScore
4.30
自引率
5.30%
发文量
194
审稿时长
6-12 weeks
期刊介绍: Journal of Ophthalmology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the anatomy, physiology and diseases of the eye. Submissions should focus on new diagnostic and surgical techniques, instrument and therapy updates, as well as clinical trials and research findings.
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