胃食管反流病与早产:单变量和多变量孟德尔随机法》(Univariate and Multivariate Mendelian Randomization)。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-08-13 eCollection Date: 2024-01-01 DOI:10.2147/IJWH.S467056
Xinyu Han, Tian Qiang Wu, Ruiting Yao, Chang Liu, Lu Chen, Xiaoling Feng
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引用次数: 0

摘要

背景:观察性研究已证实胃食管反流病(GERD)与早产(PTB)之间存在联系。然而,这些相关性可能会受到残余混杂因素或反向因果关系的影响,从而导致两者之间的联系模糊不清。本研究的目的是评估基因预测的胃食管反流与早产之间的关系:最初,我们利用公开的全基因组关联研究(GWAS)数据进行了双向单变量孟德尔随机化(UVMR)分析。为确定胃食管反流病与肺结核之间的因果关系,我们采用的主要分析方法是反方差加权技术(IVW)。随后,我们利用多变量孟德尔随机化(MVMR)来调整可能影响结果的潜在因素,如体重指数(BMI)、出生时母亲吸烟情况、教育程度、家庭收入和汤森贫困指数(TDI)。此外,我们还进行了一系列综合敏感性分析,以评估磁共振结果的可靠性:结果:UVMR 分析结果显示胃食管反流病与 PTB 之间存在显著相关性(几率比 [OR]:1.344-2.439):加权中位法(OR=1.591,95% CI=1.094-2.315,P=0.015)显示的结果一致。反向 MR 结果表明,PTB 与胃食管反流病发病率之间没有因果关系。此外,敏感性分析没有发现异质性或水平多向性,"撇一除一 "检查证实因果关系估计不太可能受到单核苷酸多态性(SNPs)效应的影响。MVMR分析表明,在考虑体重指数(BMI)、出生时母亲吸烟、教育程度、家庭收入和TDI后,胃食管反流病与肺结核之间的因果关系仍然存在(OR=1.921,95% CI=1.401-2.634,P=5.08E-05):本研究提供的证据表明,遗传预测性胃食管反流病可增加患 PTB 的风险。因此,建议对患有胃食管反流病的孕妇进行重点筛查,以发现先天性肺结核的最初征兆,并及时采取干预策略以延长妊娠期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gastroesophageal Reflux Disease and Preterm Birth: Univariate and Multivariate Mendelian Randomization.

Background: Observational studies have established a connection between Gastroesophageal reflux disease (GERD) and preterm birth (PTB). Nevertheless, these correlations can be affected by residual confounding or reverse causality, resulting in ambiguity regarding the connection. The objective of this study was to assess the relationship between genetically predicted GERD and PTB.

Methods: Initially, we performed bidirectional univariate Mendelian randomization (UVMR) analysis utilizing publicly accessible genome-wide association studies (GWAS) data. The primary analytical approach employed to determine the causal impact between GERD and PTB is the inverse variance weighted technique (IVW). Subsequently, we utilized multivariate Mendelian randomization (MVMR) to adjust for potential factors that could influence the results, such as body mass index (BMI), maternal smoking around birth, educational attainment, household income, and Townsend deprivation index (TDI). Furthermore, we performed a sequence of comprehensive sensitivity analyses to assess the reliability of our MR findings.

Results: The UVMR analysis results showed a significant correlation between GERD and PTB (odds ratio [OR]: 1.810; 95% confidence interval [CI]: 1.344-2.439; P=9.60E-05) in the IVW model, and the Weighted median method (OR=1.591, 95% CI=1.094-2.315, P=0.015) revealed consistent results. The inverse MR findings suggest no causal link between PTB and the incidence of GERD. In addition, the sensitivity analysis did not detect heterogeneity or horizontal pleiotropy, and the "leave-one-out" examination confirmed that the causal estimation is unlikely to be influenced by the single nucleotide polymorphisms (SNPs) effect. The MVMR analysis demonstrated that the causal association between GERD and PTB still existed after considering BMI, maternal smoking around birth, educational attainment, household income, and TDI (OR=1.921, 95% CI=1.401-2.634, P=5.08E-05).

Conclusion: This study presents evidence indicating that genetically predicted GERD can heighten the risk of PTB. Therefore, it is advisable to perform focused screening for pregnant women with GERD in order to find the initial signs of PTB and promptly apply intervention strategies to extend the duration of pregnancy.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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