HOPE 队列:队列概况和选择偏差评估。

IF 7.7 1区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
European Journal of Epidemiology Pub Date : 2024-08-01 Epub Date: 2024-08-19 DOI:10.1007/s10654-024-01150-4
Mette-Marie Zacher Kjeldsen, Merete Lund Mægbæk, Xiaoqin Liu, Malene Galle Madsen, Mette Bliddal, Sofie Egsgaard, Kathrine Bang Madsen, Trine Munk-Olsen
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引用次数: 0

摘要

HOPE 队列是一个持续跟踪的丹麦全国性队列,拥有 170,218 名产妇(142,795 名母亲)的产后抑郁症(PPD)症状和诊断信息。这些数据与有关母亲、其伴侣、父母和子女的健康和社会经济信息的大量登记数据相联系。该队列概况旨在概述数据收集和内容、描述特征并评估潜在的选择偏差。使用爱丁堡产后抑郁量表对丹麦 98 个市镇中的 67 个进行了产后抑郁筛查,时间跨度为 2015 年 1 月至 2021 年 12 月。这些数据与 PPD 诊断登记数据(通过药物处方和医院联系确认)以及背景信息相关联。群组特征与来源人群进行了比较,来源人群定义为同一时期居住在丹麦的所有分娩妇女(452207 例分娩)。通过比较队列与来源人群之间五种公认关联的几率比,对潜在的选择偏差进行了评估。HOPE 群组拥有 170,218 例分娩(占来源人群的 38%)的信息,涉及 142,795 名独特的母亲。HOPE 群组与来源人群在大多数特征上仅有细微差别,但在特定特征上观察到较大差异,其中最年轻和最年长年龄组、有三个以上孩子或双胞胎/三胞胎的妇女以及在丹麦以外出生的妇女所占比例较低。在两个人群中,发现了五种成熟关联中的类似关联。在所研究的五种关联中,没有迹象表明存在选择偏差,HOPE 队列在重要的围产期特征方面对来源人群具有代表性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The HOPE cohort: cohort profile and evaluation of selection bias.

The HOPE cohort: cohort profile and evaluation of selection bias.

The HOPE cohort is a Danish nationwide cohort with ongoing follow-up, holding information on postpartum depression (PPD) symptoms and diagnoses on 170,218 childbirths (142,795 unique mothers). These data have been linked with extensive register data on health and socioeconomic information on the mothers, their partners, parents, and children. This cohort profile aimed to provide an overview of the data collection and content, describe characteristics, and evaluate potential selection bias. PPD screenings, using the Edinburgh Postnatal Depression Scale, were collected from 67 of the 98 Danish municipalities, covering the period January 2015 to December 2021. This data was linked with register data on PPD diagnoses (identified through medication prescriptions and hospital contacts) as well as background information. Cohort characteristics were compared to the source population, defined as all childbirths by women residing in Denmark during the same period (452,207 childbirths). Potential selection bias was evaluated by comparing odds ratios of five well-established associations between the cohort and the source population. The HOPE cohort holds information on 170,218 childbirths (38% of the source population) involving 142,795 unique mothers. The HOPE cohort only differed slightly from the source population on most characteristics examined, but larger differences were observed on specific characteristics with an underrepresentation of the youngest and oldest age groups, women with more than three children or twins/triplets, and women born outside Denmark. Similar associations were identified across the two populations within the five well-established associations. There was no indication of selection bias on the five examined associations, and the HOPE cohort is representative of the source population on important perinatal characteristics.

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来源期刊
European Journal of Epidemiology
European Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
21.40
自引率
1.50%
发文量
109
审稿时长
6-12 weeks
期刊介绍: The European Journal of Epidemiology, established in 1985, is a peer-reviewed publication that provides a platform for discussions on epidemiology in its broadest sense. It covers various aspects of epidemiologic research and statistical methods. The journal facilitates communication between researchers, educators, and practitioners in epidemiology, including those in clinical and community medicine. Contributions from diverse fields such as public health, preventive medicine, clinical medicine, health economics, and computational biology and data science, in relation to health and disease, are encouraged. While accepting submissions from all over the world, the journal particularly emphasizes European topics relevant to epidemiology. The published articles consist of empirical research findings, developments in methodology, and opinion pieces.
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