Seroprevalence of infectious bursal disease and its associated risk factors in Ethiopia: a systematic review and meta-analysis.

The poultry population is an integral part of Ethiopia's Gross Domestic Product (GDP) but, due to various infectious diseases such as infectious bursal disease (IBD), the expected economic impact in the country remains limited. The status of the disease in Ethiopia is obscured; thus, a systematic review and meta-analysis were employed to estimate the overall pooled prevalence of IBD in Ethiopia. Meta-analysis was conducted to determine the effects of each identified risk factor, while meta-regression and sub-group analysis were employed to assess the relationship between study-level covariates and effect size. The pooled prevalence of IBD in Ethiopia was 69.4% (95% CI 30.7-96.2), while the pooled logit prevalence was 0.94 (95% CI: 0.68-1.20) with significant inter-study variance (Q test = 948.28, df = 43, P < 0.001; τ² = 0.71, I²= 95.47%). A small-study effect was detected in the regression-based Egger test (Prob > |z| < 0.0001). Significant variation was observed among different groups such as sex, age, breed, and type of farm of the chickens. The effect size for the study period from 2018 to 2021 was significantly lower by -0.204 compared to the study period from 2009 to 2015 (P < 0.0001. In conclusion, the IBD pooled prevalence estimate is high, even though the number of studies in the country is insufficient. The high prevalence of the disease requires prompt attention from all stakeholders in the sector to bring it under control through comprehensive disease prevention and control intervention strategies.