儿童时期不同食物来源的钙摄入量与青春期心脏代谢风险之间的关系：XXI 代出生队列。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2024-08-18 DOI:10.1111/ijpo.13158

Sara Silva, Milton Severo, Carla Lopes

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引用次数: 0

摘要

背景：钙摄入量与脂肪率降低有关，但很少有研究探讨不同来源的钙与年轻人群心脏代谢指标的纵向关系：目的：前瞻性估计 4、7 和 10 岁时乳制品和非乳制品钙摄入量与 13 岁时心脏代谢风险之间的关系：样本包括 4017 名来自 XXI 代出生队列的参与者。饮食数据通过 3 天的食物日记收集。13岁时的心脏代谢群是通过概率高斯混合模型估算的（腰围[WC]z-score、HOMA-IR；高密度脂蛋白胆固醇、甘油三酯和收缩压[BP]）。多变量线性回归模型和逻辑回归模型用于估计相关性：结果：在对混杂因素进行调整后，钙摄入量（/100 毫克）与体重指数（BMI）（β = -0.02，95% CI：-0.04；-0.01）、腹围（厘米）（β = -0.23，95% CI：-0.36；-0.11）和舒张压（毫米汞柱）（β = -0.14，95% CI：-0.26；-0.03）呈显著负相关。在对总能量摄入进行额外调整后，相关性失去了统计学意义。7 岁时从牛奶中摄入的钙与体重减轻成反比（β = -0.25，95% CI：-0.48；-0.03），10 岁时从酸奶中摄入的钙与较高的体重指数（β = 0.08，95% CI：0.03；0.13）和体重减轻（β = 0.54，95% CI：0.12；0.96）相关。4、7、10 岁时从蔬菜中摄取的钙可降低日后的心脏代谢风险（OR = 0.71；OR = 0.84；OR = 0.98）：本研究支持钙对青少年心脏代谢健康的保护作用，尤其是来自蔬菜的钙。

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Association between calcium intake from different food sources during childhood and cardiometabolic risk on adolescence: The Generation XXI birth cohort

Background

Calcium intake has been associated with lower adiposity, but few studies explored the longitudinal relation of calcium from different sources and cardiometabolic markers in young population.

Objective

Prospectively estimate the association between dairy and non-dairy calcium intake at 4, 7, and 10 years (y) of age and cardiometabolic risk at 13 y.

Methods

The sample included 4017 participants from the Generation XXI birth cohort. Dietary data were collected from a 3-day food diary. Cardiometabolic clusters at 13 y were estimated by a probabilistic Gaussian mixture model (z-score of waist circumference [WC], HOMA-IR; HDL cholesterol, triglycerides, and systolic blood pressure [BP]). Multivariable linear and logistic regression models were used to estimate associations.

Results

Calcium intake (/100 mg), after adjustment for confounders, was negatively and significantly associated with body mass index (BMI) (β = −0.02, 95% CI: −0.04; −0.01), WC (cm) (β = −0.23, 95% CI: −0.36; −0.11), and diastolic BP (mmHg) (β = −0.14, 95% CI: −0.26; −0.03). After additional adjustment for total energy intake, associations lose statistical significance. Calcium intake from milk at 7 y was inversely associated with WC (β = −0.25, 95% CI: −0.48; −0.03) and from yogurt at 10 y was associated with higher BMI (β = 0.08, 95% CI: 0.03; 0.13) and WC (β = 0.54, 95% CI: 0.12; 0.96). Calcium from vegetables at 4, 7, 10 y reduces later cardiometabolic risk (OR = 0.71; OR = 0.84; OR = 0.98, respectively).

Conclusions

This study supports a protective effect of calcium on adolescents' cardiometabolic health, especially from vegetables.

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.