生姜精油通过阻断小鼠体内的 NLRP3 炎性体和重塑肠道微生物群-LPS-TLR4 通路来预防 NASH 的发展。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Suraphan Panyod, Wei-Kai Wu, Ya-Chi Hsieh, Yea-Jing Tseng, Sin-Yi Peng, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu, Lee-Yan Sheen
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引用次数: 0

摘要

背景:饮食和肠道微生物群对非酒精性脂肪性肝炎(NASH)的发展起着重要作用。高脂饮食(HFDs)会改变肠道微生物群的组成,诱发肠道菌群失调和肠道屏障渗漏,这有利于包括脂多糖(LPS)在内的病原体相关分子模式进入肝脏,并引发非酒精性脂肪性肝炎的炎症。目前治疗 NASH 的药物有不良副作用;然而,一些具有保肝作用的食物和草药可作为预防 NASH 的替代方法:方法:我们研究了生姜精油(GEO)与含棕榈油的高密度脂蛋白胆固醇(HFDs)在LPS注射小鼠NASH模型中的作用:结果:GEO降低了血浆丙氨酸氨基转移酶水平和肝脏促炎细胞因子水平;提高了抗氧化剂过氧化氢酶、谷胱甘肽还原酶和谷胱甘肽水平,从而预防了NASH。GEO 通过介导 NLR 家族含吡咯啉结构域 3(NLRP3)炎性体和 LPS/Toll-like receptor four(TLR4)信号通路缓解肝脏炎症。GEO进一步增加了有益细菌的数量,降低了NASH相关细菌的数量:本研究表明,GEO 可预防 NASH 的发展,这可能与肠道微生物群的改变和 LPS/TLR4/NF-κB 通路的抑制有关。因此,GEO可作为预防NASH的膳食补充剂,具有广阔的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice.

Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice.

Background: Diet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH.

Methods: We investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model.

Results: GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance.

Conclusion: This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.

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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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