生姜精油通过阻断小鼠体内的 NLRP3 炎性体和重塑肠道微生物群-LPS-TLR4 通路来预防 NASH 的发展。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Suraphan Panyod, Wei-Kai Wu, Ya-Chi Hsieh, Yea-Jing Tseng, Sin-Yi Peng, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu, Lee-Yan Sheen
{"title":"生姜精油通过阻断小鼠体内的 NLRP3 炎性体和重塑肠道微生物群-LPS-TLR4 通路来预防 NASH 的发展。","authors":"Suraphan Panyod, Wei-Kai Wu, Ya-Chi Hsieh, Yea-Jing Tseng, Sin-Yi Peng, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu, Lee-Yan Sheen","doi":"10.1038/s41387-024-00306-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Diet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH.</p><p><strong>Methods: </strong>We investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model.</p><p><strong>Results: </strong>GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance.</p><p><strong>Conclusion: </strong>This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.</p>","PeriodicalId":19339,"journal":{"name":"Nutrition & Diabetes","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329514/pdf/","citationCount":"0","resultStr":"{\"title\":\"Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice.\",\"authors\":\"Suraphan Panyod, Wei-Kai Wu, Ya-Chi Hsieh, Yea-Jing Tseng, Sin-Yi Peng, Rou-An Chen, Huai-Syuan Huang, Yi-Hsun Chen, Ting-Chin David Shen, Chi-Tang Ho, Chun-Jen Liu, Hsiao-Li Chuang, Chi-Chang Huang, Ming-Shiang Wu, Lee-Yan Sheen\",\"doi\":\"10.1038/s41387-024-00306-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Diet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH.</p><p><strong>Methods: </strong>We investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model.</p><p><strong>Results: </strong>GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance.</p><p><strong>Conclusion: </strong>This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.</p>\",\"PeriodicalId\":19339,\"journal\":{\"name\":\"Nutrition & Diabetes\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-08-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329514/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nutrition & Diabetes\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41387-024-00306-1\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nutrition & Diabetes","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41387-024-00306-1","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

背景:饮食和肠道微生物群对非酒精性脂肪性肝炎(NASH)的发展起着重要作用。高脂饮食(HFDs)会改变肠道微生物群的组成,诱发肠道菌群失调和肠道屏障渗漏,这有利于包括脂多糖(LPS)在内的病原体相关分子模式进入肝脏,并引发非酒精性脂肪性肝炎的炎症。目前治疗 NASH 的药物有不良副作用;然而,一些具有保肝作用的食物和草药可作为预防 NASH 的替代方法:方法:我们研究了生姜精油(GEO)与含棕榈油的高密度脂蛋白胆固醇(HFDs)在LPS注射小鼠NASH模型中的作用:结果:GEO降低了血浆丙氨酸氨基转移酶水平和肝脏促炎细胞因子水平;提高了抗氧化剂过氧化氢酶、谷胱甘肽还原酶和谷胱甘肽水平,从而预防了NASH。GEO 通过介导 NLR 家族含吡咯啉结构域 3(NLRP3)炎性体和 LPS/Toll-like receptor four(TLR4)信号通路缓解肝脏炎症。GEO进一步增加了有益细菌的数量,降低了NASH相关细菌的数量:本研究表明,GEO 可预防 NASH 的发展,这可能与肠道微生物群的改变和 LPS/TLR4/NF-κB 通路的抑制有关。因此,GEO可作为预防NASH的膳食补充剂,具有广阔的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice.

Ginger essential oil prevents NASH progression by blocking the NLRP3 inflammasome and remodeling the gut microbiota-LPS-TLR4 pathway in mice.

Background: Diet and gut microbiota contribute to non-alcoholic steatohepatitis (NASH) progression. High-fat diets (HFDs) change gut microbiota compositions, induce gut dysbiosis, and intestinal barrier leakage, which facilitates portal influx of pathogen-associated molecular patterns including lipopolysaccharides (LPS) to the liver and triggers inflammation in NASH. Current therapeutic drugs for NASH have adverse side effects; however, several foods and herbs that exhibit hepatoprotection could be an alternative method to prevent NASH.

Methods: We investigated ginger essential oil (GEO) against palm oil-containing HFDs in LPS-injected murine NASH model.

Results: GEO reduced plasma alanine aminotransferase levels and hepatic pro-inflammatory cytokine levels; and increased antioxidant catalase, glutathione reductase, and glutathione levels to prevent NASH. GEO alleviated hepatic inflammation through mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome and LPS/Toll-like receptor four (TLR4) signaling pathways. GEO further increased beneficial bacterial abundance and reduced NASH-associated bacterial abundance.

Conclusion: This study demonstrated that GEO prevents NASH progression which is probably associated with the alterations of gut microbiota and inhibition of the LPS/TLR4/NF-κB pathway. Hence, GEO may offer a promising application as a dietary supplement for the prevention of NASH.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信