肿瘤如何劫持巨噬细胞逃避免疫？

IF 23.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2024-08-16 DOI:10.1038/s43018-024-00808-y

Anders Hofer

引用次数: 0

摘要

癌症对免疫检查点阻断剂的抵抗力经常被观察到。现在的研究表明，胰腺癌细胞会通过过度表达胞苷脱氨酶来创造一种肿瘤微环境，使其免受免疫疗法的影响。这导致二磷酸尿苷的产生增加，从而吸引免疫抑制巨噬细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

How tumors hijack macrophages for immune evasion

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How tumors hijack macrophages for immune evasion

Resistance of cancers to immune checkpoint blockades is frequently observed. Pancreatic cancer cells are now shown to create a tumor microenvironment that protects them from immunotherapy by overexpression of cytidine deaminase. This leads to increased production of uridine diphosphate that attracts immunosuppressive macrophages.

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.