中国中老年人代谢综合征严重程度与虚弱进展的关系:一项纵向研究。

IF 8.5 1区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Peng Zeng, Minjie Li, JiXing Cao, Long Zeng, Cheng Jiang, Feng Lin
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引用次数: 0

摘要

背景:代谢综合征(MetS)的二元诊断无法准确评估其严重程度,MetS严重程度与虚弱进展之间的关系仍未得到充分阐明。本研究旨在阐明中国中老年人群中 MetS 严重程度与虚弱进展之间的关系:方法:纳入 2011-2018 年中国健康与退休纵向研究(CHARLS)的参与者进行纵向分析。该研究采用基于32项健康缺陷的虚弱指数(FI)来诊断虚弱并评估虚弱指数的变化轨迹。该研究采用了一个年龄-性别-种族特异性 MetS 评分模型(MetS 评分)来评估中国成年人代谢综合征的严重程度。2012年至2015年的累计MetS得分计算公式为(第 1 波的 MetS 评分 + 第 3 波的 MetS 评分)/2 × 时间(2015 - 2012)。采用 Cox 回归/logistic 回归和线性混合模型评估 MetS 评分、累积 MetS 评分与虚弱风险和轨迹之间的关联。限制性三次样条(RCS)模型用于检测潜在的非线性关联:MetS 评分越高,虚弱风险越高(每增加 1 SD 的 HR = 1.205;95%CI:1.14 至 1.273),FI 轨迹越快(每增加 1 SD 的 β = 每年 0.113;95%CI:每年 0.075 至 0.15)。使用累积 MetS 评分评估 MetS 评分的变化表明,累积 MetS 评分每增加 1 SD,虚弱风险就会增加 22.2%(OR = 1.222;95%CI:1.133 至 1.319),并加快 FI 的增加速度(β = 每年 0.098;95%CI:每年 0.058 至 0.138)。RCS 模型结果显示,MetS 评分和累积 MetS 评分与虚弱风险之间存在剂量反应曲线关系。分层分析表明,各亚组之间的关系是一致的。交互作用结果表明,在男性和 60 岁以下的人群中,MetS 评分可能会加速 FI 的增加,这一结果在两个模型中都是一致的:我们的研究结果表明,MetS 的严重程度与中老年人体弱进展之间存在正相关,这突出表明迫切需要早期识别 MetS 并采取有针对性的干预措施来降低体弱风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of metabolic syndrome severity with frailty progression among Chinese middle and old-aged adults: a longitudinal study.

Background: The binary diagnosis of Metabolic Syndrome(MetS) fails to accurately evaluate its severity, and the association between MetS severity and frailty progression remains inadequately elucidated. This study aims to clarify the relationship between the severity of MetS and the progression of frailty among the middle-aged and elderly population in China.

Method: Participants from the 2011-2018 China Health and Retirement Longitudinal Study(CHARLS) were included for a longitudinal analysis. The study employs a frailty index(FI) based on 32 health deficits to diagnose frailty and to assess FI trajectories. An age-sex-ethnicity-specific MetS scoring model (MetS score) was used to assess metabolic syndrome severity in Chinese adults. The Cumulative MetS score from 2012 to 2015 was calculated using the formula: (MetS score in wave 1 + MetS score in wave 3) / 2 × time(2015 - 2012). The association between MetS score, Cumulative MetS score, and the risk and trajectory of frailty were evaluated using Cox regression/logistic regression, and linear mixed models. Restricted Cubic Splines(RCS) models were utilized to detect potential non-linear associations.

Results: A higher MetS score was significantly associated with an increased risk of frailty(HR per 1 SD increase = 1.205; 95%CI: 1.14 to 1.273) and an accelerated FI trajectory(β per 1 SD increase = 0.113 per year; 95%CI: 0.075 to 0.15 per year). Evaluating changes in MetS score using a Cumulative MetS score indicated that each 1 SD increase in the Cumulative MetS score increased the risk of frailty by 22.2%(OR = 1.222; 95%CI: 1.133 to 1.319) and accelerated the rate of increase in FI(β = 0.098 per year; 95%CI: 0.058 to 0.138 per year). RCS model results demonstrated a dose-response curve relationship between MetS score and Cumulative MetS score with frailty risk. Stratified analysis showed consistency across subgroups. The interaction results indicate that in males and individuals under aged 60, MetS score may accelerate the increase in FI, a finding consistent across both models.

Conclusions: Our findings underscore the positive correlation between the severity of MetS and frailty progression in the middle-aged and elderly, highlighting the urgent need for early identification of MetS and targeted interventions to reduce the risk of frailty.

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来源期刊
Cardiovascular Diabetology
Cardiovascular Diabetology 医学-内分泌学与代谢
CiteScore
12.30
自引率
15.10%
发文量
240
审稿时长
1 months
期刊介绍: Cardiovascular Diabetology is a journal that welcomes manuscripts exploring various aspects of the relationship between diabetes, cardiovascular health, and the metabolic syndrome. We invite submissions related to clinical studies, genetic investigations, experimental research, pharmacological studies, epidemiological analyses, and molecular biology research in this field.
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