SPECT/CT 成像:量化脊柱和骨盆中的 99mTc-MDP 浓度。

IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Xiaoguang Hou, Yibo He, Guobing Liu, Shuguang Chen, Hongcheng Shi
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引用次数: 0

摘要

研究目的本研究旨在通过使用一体化SPECT/CT扫描仪对正常脊柱和骨盆中99mTc-MDP的SUV进行定量测量并比较各种归一化方法,从而确定一个相对稳健的SUV以指导临床实践:2017年6月至2019年9月期间,共有500名肿瘤患者(平均年龄60.9岁;男性占66.0%)接受了99m锝-MDP的骨SPECT/CT扫描,并被纳入这项回顾性研究。根据患者的体重(BW)、瘦体重(LBM)、骨矿物质含量(BMC)、体表面积(BSA)和体重指数(BMI)计算出了 4962 块脊柱骨和骨盆骨的平均 SUV(SUVmean),分别定义为 SUVbw、SUVlbm、SUVbmc、SUVbsa 和 SUVbmi。比较了上述参数的变异系数(CoVs),并使用相关分析和多元线性回归分析比较了这些参数受性别、年龄、身高、体重、BMI 和 CT 值的影响程度:正常脊柱和骨盆的平均 SUV 值变化相对较大:SUVbw 为 4.573 ± 1.972,SUVlbm 为 3.555 ± 1.517,SUVbmc 为 0.163 ± 0.071,SUVbsa 为 0.124 ± 0.052,SUVbmi 为 1.668 ± 0.732。总体而言,与其他 SUV 相比,SUVbsa 在所有椎骨和骨盆中的 CoV 值相对最低(42.1%)。在相关性分析中,所有 SUV 值都与年龄和 CT 值有微弱但显著的相关性。在回归分析中,SUVbsa仅受年龄、体重指数和CT值的独立影响。这些变量对SUVbsa的影响均小于对常规SUVbw的影响:结论:定量骨SPECT/CT得出的99m锝-MDP在正常骨中的SUV值可作为评估肿瘤骨转移的参考值,但应根据具体部位进行评估。在所有SUV归一化变异中,SUVbsa表现出更高的稳健性,这表明它具有潜在的临床应用价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

SPECT/CT imaging: quantifying 99mTc-MDP concentration in the spine and pelvis

SPECT/CT imaging: quantifying 99mTc-MDP concentration in the spine and pelvis

Objective

This study aimed to identify a relatively robust SUV for guiding clinical practice through quantitative measurement and comparison of various normalization methods based on the SUV of 99mTc-MDP in the normal spine and pelvis using an integrated SPECT/CT scanner.

Methods

Between June 2017 and September 2019, a total of 500 oncology patients (mean age, 60.9; men, 66.0%) who underwent bone SPECT/CT scans with 99mTc-MDP were enrolled in this retrospective study. The mean SUV (SUVmean) of 4962 spinal and pelvic bones was calculated based on the patients’ body weight (BW), lean body mass (LBM), bone mineral content (BMC), body surface area (BSA), and body mass index (BMI), defined as SUVbw, SUVlbm, SUVbmc, SUVbsa, and SUVbmi, respectively. The coefficients of variation (CoVs) of the aforementioned parameters were compared, and the correlation and multiple linear regression analyses were used to compare the extent to which these parameters were affected by sex, age, height, weight, BMI, and CT values.

Results

The average SUVs in the normal spine and pelvis displayed a relatively wide variability: 4.573 ± 1.972 for SUVbw, 3.555 ± 1.517 for SUVlbm, 0.163 ± 0.071 for SUVbmc, 0.124 ± 0.052 for SUVbsa, and 1.668 ± 0.732 for SUVbmi. In general, SUVbsa had relatively lowest CoV (42.1%) in all vertebrae and pelvis compared with other SUVs. For correlation analyses, all SUVs displayed weak but significant correlations with age and CT values. For regression analyses, SUVbsa was influenced only by age, BMI, and CT values independently. The effects of these variables on SUVbsa were all smaller than those on conventional SUVbw.

Conclusions

The SUVs of 99mTc-MDP in normal bone derived from quantitative bone SPECT/CT could serve as a reference for evaluating tumor bone metastasis, but it should be assessed on a site-specific basis. SUVbsa exhibited superior robustness among all the SUV normalization variations, indicating potential clinical applications.

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来源期刊
Annals of Nuclear Medicine
Annals of Nuclear Medicine 医学-核医学
CiteScore
4.90
自引率
7.70%
发文量
111
审稿时长
4-8 weeks
期刊介绍: Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.
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