灵长类多巴胺能系统的进化创新

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Current Opinion in Genetics & Development Pub Date : 2024-08-16 DOI:10.1016/j.gde.2024.102236

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引用次数: 0

摘要

与其他脊椎动物相比，人类大脑进化出了独特的能力。这些进化特性的机理基础仍然是生物学中的一个基本问题，因为它关系到人类认知能力和行为方式的起源，以及人类特有的神经精神疾病和神经退行性疾病。将人脑与非人灵长类动物和其他哺乳动物的大脑进行比较后发现，神经调节系统的差异，尤其是多巴胺能系统的差异，可能会导致某些行为和认知能力的改变，包括更容易患上某些脑部疾病。在这篇综述中，我们将重点介绍和讨论有关人类和灵长类动物多巴胺能系统特异性改变的最新发现，重点是解剖学、电路和分子特性方面的差异。

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Evolutionary innovations in the primate dopaminergic system

The human brain has evolved unique capabilities compared to other vertebrates. The mechanistic basis of these derived traits remains a fundamental question in biology due to its relevance to the origin of our cognitive abilities and behavioral repertoire, as well as to human-specific aspects of neuropsychiatric and neurodegenerative diseases. Comparisons of the human brain to those of nonhuman primates and other mammals have revealed that differences in the neuromodulatory systems, especially in the dopaminergic system, may govern some of these behavioral and cognitive alterations, including increased vulnerability to certain brain disorders. In this review, we highlight and discuss recent findings of human- and primate-specific alterations of the dopaminergic system, focusing on differences in anatomy, circuitry, and molecular properties.

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来源期刊

Current Opinion in Genetics & Development 生物-细胞生物学

CiteScore

7.90

自引率

0.00%

发文量

102

审稿时长

1 months

期刊介绍： Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)