Swathi Kaliki, Vijitha S Vempuluru, Komal Rajendra Bakal, Samten Dorji, Vishakha Tanna, Charlotte N Shields, Samuel J Fallon, Vishal Raval, Alia Ahmad, Asma Mushtaq, Mahvish Hussain, Yacoub A Yousef, Mona Mohammad, Soma Rani Roy, Fahmida Huque, Ushakova Tatiana, Serov Yuri, Polyakov Vladimir, Sandro Casavilca Zambrano, Sandra Alarcón-León, Cinthya Valdiviezo-Zapata, Maria Vargas-Martorellet, Cynthia Gutierrez-Chira, Mario Buitrago, Joana Sánchez Ortiz, Rosdali Diaz-Coronado, Devjyoti Tripathy, Suryasnata Rath, Gaurav Patil, Jesse L Berry, Sarah Pike, Brianne Brown, Mika Tanabe, Shahar Frenkel, Maya Eiger-Moscovich, Jacob Pe'er, Carol L Shields, Ralph C Eagle, Andrea Laiton, Ana Maria Velasco, Katherine Vega, Joseph DeSimone, Kavya Madhuri Bejjanki, Anasua Ganguly Kapoor, Anusha Venkataraman, Victoria Bryant, M Ashwin Reddy, Mandeep S Sagoo, G Baker Hubbard, Corrina P Azarcon, Thomas A Olson, Hans Grossniklaus, Olivia Rolfe, Sandra E Staffieri, Roderick O'Day, Anu A Mathew, James E Elder, John D McKenzie, Ido Didi Fabian, Rachel Shemesh, Vicktoria Vishnevskia-Dai, Mohammed Hasnat Ali, Saumya Jakati, Dilip K Mishra, Vijay Anand Reddy Palkonda
{"title":"原发性去核术后视网膜母细胞瘤的高危组织病理学特征：来自五大洲 1426 名患者的全球研究。","authors":"Swathi Kaliki, Vijitha S Vempuluru, Komal Rajendra Bakal, Samten Dorji, Vishakha Tanna, Charlotte N Shields, Samuel J Fallon, Vishal Raval, Alia Ahmad, Asma Mushtaq, Mahvish Hussain, Yacoub A Yousef, Mona Mohammad, Soma Rani Roy, Fahmida Huque, Ushakova Tatiana, Serov Yuri, Polyakov Vladimir, Sandro Casavilca Zambrano, Sandra Alarcón-León, Cinthya Valdiviezo-Zapata, Maria Vargas-Martorellet, Cynthia Gutierrez-Chira, Mario Buitrago, Joana Sánchez Ortiz, Rosdali Diaz-Coronado, Devjyoti Tripathy, Suryasnata Rath, Gaurav Patil, Jesse L Berry, Sarah Pike, Brianne Brown, Mika Tanabe, Shahar Frenkel, Maya Eiger-Moscovich, Jacob Pe'er, Carol L Shields, Ralph C Eagle, Andrea Laiton, Ana Maria Velasco, Katherine Vega, Joseph DeSimone, Kavya Madhuri Bejjanki, Anasua Ganguly Kapoor, Anusha Venkataraman, Victoria Bryant, M Ashwin Reddy, Mandeep S Sagoo, G Baker Hubbard, Corrina P Azarcon, Thomas A Olson, Hans Grossniklaus, Olivia Rolfe, Sandra E Staffieri, Roderick O'Day, Anu A Mathew, James E Elder, John D McKenzie, Ido Didi Fabian, Rachel Shemesh, Vicktoria Vishnevskia-Dai, Mohammed Hasnat Ali, Saumya Jakati, Dilip K Mishra, Vijay Anand Reddy Palkonda","doi":"10.1097/IAE.0000000000004250","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents.</p><p><strong>Methods: </strong>Retrospective study of 1426 primarily enucleated RB eyes from five continents.</p><p><strong>Results: </strong>Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathology features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, p=0.001), post-laminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, p=0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, p=0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, p=0.68). Adjuvant chemotherapy with/without orbital radiotherapy was given in 761 (53%) patients. Based on Kaplan-Meier estimates in different continents (AS vs. AUS vs. EUR vs. NA vs. SA), the 6-year risk of orbital tumor recurrence was 5% vs. 2% vs. 0% vs. 0% vs. 12% (p<0.001), systemic metastasis was reported in 8% vs. 5% vs. 2% vs. 0% vs. 13% (p=0.001), and death in 10% vs. 3% vs. 2% vs. 0% vs. 11% (p<0.001) patients.</p><p><strong>Conclusion: </strong>There is a wide variation in the infiltrative histopathology features of RB across continents, resulting in variable outcomes. SA and AS had a higher risk of orbital tumor recurrence, systemic metastasis, and death compared to AUS, EUR, and NA.</p>","PeriodicalId":54486,"journal":{"name":"Retina-The Journal of Retinal and Vitreous Diseases","volume":" ","pages":""},"PeriodicalIF":2.3000,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559960/pdf/","citationCount":"0","resultStr":"{\"title\":\"High-Risk Histopathological Features of Retinoblastoma following Primary Enucleation: A Global Study of 1426 Patients from 5 Continents.\",\"authors\":\"Swathi Kaliki, Vijitha S Vempuluru, Komal Rajendra Bakal, Samten Dorji, Vishakha Tanna, Charlotte N Shields, Samuel J Fallon, Vishal Raval, Alia Ahmad, Asma Mushtaq, Mahvish Hussain, Yacoub A Yousef, Mona Mohammad, Soma Rani Roy, Fahmida Huque, Ushakova Tatiana, Serov Yuri, Polyakov Vladimir, Sandro Casavilca Zambrano, Sandra Alarcón-León, Cinthya Valdiviezo-Zapata, Maria Vargas-Martorellet, Cynthia Gutierrez-Chira, Mario Buitrago, Joana Sánchez Ortiz, Rosdali Diaz-Coronado, Devjyoti Tripathy, Suryasnata Rath, Gaurav Patil, Jesse L Berry, Sarah Pike, Brianne Brown, Mika Tanabe, Shahar Frenkel, Maya Eiger-Moscovich, Jacob Pe'er, Carol L Shields, Ralph C Eagle, Andrea Laiton, Ana Maria Velasco, Katherine Vega, Joseph DeSimone, Kavya Madhuri Bejjanki, Anasua Ganguly Kapoor, Anusha Venkataraman, Victoria Bryant, M Ashwin Reddy, Mandeep S Sagoo, G Baker Hubbard, Corrina P Azarcon, Thomas A Olson, Hans Grossniklaus, Olivia Rolfe, Sandra E Staffieri, Roderick O'Day, Anu A Mathew, James E Elder, John D McKenzie, Ido Didi Fabian, Rachel Shemesh, Vicktoria Vishnevskia-Dai, Mohammed Hasnat Ali, Saumya Jakati, Dilip K Mishra, Vijay Anand Reddy Palkonda\",\"doi\":\"10.1097/IAE.0000000000004250\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents.</p><p><strong>Methods: </strong>Retrospective study of 1426 primarily enucleated RB eyes from five continents.</p><p><strong>Results: </strong>Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathology features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, p=0.001), post-laminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, p=0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, p=0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, p=0.68). Adjuvant chemotherapy with/without orbital radiotherapy was given in 761 (53%) patients. Based on Kaplan-Meier estimates in different continents (AS vs. AUS vs. EUR vs. NA vs. SA), the 6-year risk of orbital tumor recurrence was 5% vs. 2% vs. 0% vs. 0% vs. 12% (p<0.001), systemic metastasis was reported in 8% vs. 5% vs. 2% vs. 0% vs. 13% (p=0.001), and death in 10% vs. 3% vs. 2% vs. 0% vs. 11% (p<0.001) patients.</p><p><strong>Conclusion: </strong>There is a wide variation in the infiltrative histopathology features of RB across continents, resulting in variable outcomes. SA and AS had a higher risk of orbital tumor recurrence, systemic metastasis, and death compared to AUS, EUR, and NA.</p>\",\"PeriodicalId\":54486,\"journal\":{\"name\":\"Retina-The Journal of Retinal and Vitreous Diseases\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.3000,\"publicationDate\":\"2024-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559960/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Retina-The Journal of Retinal and Vitreous Diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1097/IAE.0000000000004250\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Retina-The Journal of Retinal and Vitreous Diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/IAE.0000000000004250","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的：评估视网膜母细胞瘤（RB）患者初次去核术后的高危组织病理学特征（HRHF），并评估各大洲患者的预后：方法：对来自五大洲的1426只主要接受去核手术的RB眼球进行回顾性研究：其中，923 只（65%）来自亚洲（AS），27 只（2%）来自澳大利亚（AUS），120 只（8%）来自欧洲（EUR），162 只（11%）来自北美洲（NA），194 只（14%）来自南美洲（SA）。根据大陆（澳大利亚 vs. 澳大利亚 vs. 欧洲 vs. 北美 vs. 南美），组织病理学特征包括大面积脉络膜侵犯（31% vs. 7% vs. 13% vs. 19% vs. 27%，P=0.001）、层状视神经后侵犯（27% vs. 0% vs. 16% vs. 27%，P=0.001）、视神经后侵犯（27% vs. 0% vs. 16% vs. 27%，P=0.001）。0% vs. 16% vs. 21% vs. 19%，p=0.0006）、巩膜浸润（5% vs. 0% vs. 4% vs. 2% vs. 7%，p=0.13）和显微镜下巩膜外浸润（4% vs. 0% vs. 27%，p=0.001）：RB的浸润组织病理学特征在各大洲之间存在很大差异，导致了不同的结果。与澳大利亚、欧洲和北美洲相比，南澳大利亚州和澳大利亚州的眼眶肿瘤复发、全身转移和死亡风险更高。
High-Risk Histopathological Features of Retinoblastoma following Primary Enucleation: A Global Study of 1426 Patients from 5 Continents.
Purpose: To evaluate high-risk histopathological features (HRHF) following primary enucleation of eyes with retinoblastoma (RB) and assess the patient outcomes across continents.
Methods: Retrospective study of 1426 primarily enucleated RB eyes from five continents.
Results: Of all, 923 (65%) were from Asia (AS), 27 (2%) from Australia (AUS), 120 (8%) from Europe (EUR), 162 (11%) from North America (NA), and 194 (14%) from South America (SA). Based on the continent (AS vs. AUS vs. EUR vs. NA vs. SA), the histopathology features included massive choroidal invasion (31% vs. 7% vs. 13% vs. 19% vs. 27%, p=0.001), post-laminar optic nerve invasion (27% vs. 0% vs. 16% vs. 21% vs. 19%, p=0.0006), scleral infiltration (5% vs. 0% vs. 4% vs. 2% vs. 7%, p=0.13), and microscopic extrascleral infiltration (4% vs. 0% vs. <1% vs. <1% vs. 4%, p=0.68). Adjuvant chemotherapy with/without orbital radiotherapy was given in 761 (53%) patients. Based on Kaplan-Meier estimates in different continents (AS vs. AUS vs. EUR vs. NA vs. SA), the 6-year risk of orbital tumor recurrence was 5% vs. 2% vs. 0% vs. 0% vs. 12% (p<0.001), systemic metastasis was reported in 8% vs. 5% vs. 2% vs. 0% vs. 13% (p=0.001), and death in 10% vs. 3% vs. 2% vs. 0% vs. 11% (p<0.001) patients.
Conclusion: There is a wide variation in the infiltrative histopathology features of RB across continents, resulting in variable outcomes. SA and AS had a higher risk of orbital tumor recurrence, systemic metastasis, and death compared to AUS, EUR, and NA.
期刊介绍：
RETINA® focuses exclusively on the growing specialty of vitreoretinal disorders. The Journal provides current information on diagnostic and therapeutic techniques. Its highly specialized and informative, peer-reviewed articles are easily applicable to clinical practice.
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