多发性硬化症患者血浆和脑脊液中的纤溶相关蛋白和脂多糖生物活性

IF 2.9 4区医学 Q3 IMMUNOLOGY

Journal of neuroimmunology Pub Date : 2024-08-12 DOI:10.1016/j.jneuroim.2024.578432

Joonas Lehikoinen , Tomas Strandin , Jukka Parantainen , Katariina Nurmi , Kari K. Eklund , Francisco J. Rivera , Antti Vaheri , Pentti J. Tienari

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引用次数: 0

摘要

凝血级联和纤溶与神经炎症有关，有报道称多发性硬化症患者的凝血系统活化增加。我们对新诊断的未经治疗的多发性硬化症患者和对照组的脑脊液（CSF）和血浆中的 D-二聚体、组织纤溶酶原激活剂（tPA）、纤溶酶原激活剂抑制剂-1（PAI-1）和细菌脂多糖（LPS）的生物活性水平进行了量化。这些分子之间以及与年龄、HLA-DRB1*15:01、体重指数和 CSF IgG 之间存在多种相关性。我们的研究结果证实了之前的发现，即与对照组相比，多发性硬化症患者的血浆 PAI-1 和 LPS 增加，这表明多发性硬化症患者的血小板功能和肠道通透性发生了变化。

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Fibrinolysis associated proteins and lipopolysaccharide bioactivity in plasma and cerebrospinal fluid in multiple sclerosis

The coagulation cascade and fibrinolysis have links with neuroinflammation and increased activation of the coagulation system has been reported in MS patients. We quantified levels of D-dimer, tissue plasminogen activator (tPA), plasminogen activator inhibitor-1 (PAI-1) and the bioactivity of bacterial lipopolysaccharide (LPS) in cerebrospinal fluid (CSF) and plasma from newly diagnosed untreated MS patients and controls. These molecules showed multiple correlations with each other as well as with age, HLA-DRB1*15:01, body-mass-index and CSF IgG. Our results confirm previous findings of increased plasma PAI-1 and LPS in MS patients compared to controls indicating changes in platelet function and gut permeability in MS.

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来源期刊

Journal of neuroimmunology 医学-免疫学

CiteScore

6.10

自引率

3.00%

发文量

154

审稿时长

37 days

期刊介绍： The Journal of Neuroimmunology affords a forum for the publication of works applying immunologic methodology to the furtherance of the neurological sciences. Studies on all branches of the neurosciences, particularly fundamental and applied neurobiology, neurology, neuropathology, neurochemistry, neurovirology, neuroendocrinology, neuromuscular research, neuropharmacology and psychology, which involve either immunologic methodology (e.g. immunocytochemistry) or fundamental immunology (e.g. antibody and lymphocyte assays), are considered for publication.