感受微风利用 RIPTAC 和诱导接近打开治疗之窗

IF 6.6 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Chemical Biology Pub Date : 2024-08-15 DOI:10.1016/j.chembiol.2024.07.013

Kyle Mangano , Patrick Ryan Potts

引用次数: 0

摘要

在本期《细胞化学生物学》（Cell Chemical Biology）杂志上，Raina 等人1 展示了一种新型化学诱导接近策略的概念验证，该策略可用于癌症靶向治疗。RIPTACs 是一种新型的诱导接近模式，它以最近激增的诱导接近模式为基础，有望在治疗癌症的同时提高安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity

In this issue of Cell Chemical Biology, Raina et al.¹ demonstrate proof of concept of a new chemical induced proximity strategy for targeted cancer therapeutics. Building on a recent surge in induced proximity modalities, RIPTACs represent a novel approach that offers promise in treating cancers with improved safety profiles.

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来源期刊

Cell Chemical Biology Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

14.70

自引率

2.30%

发文量

143

期刊介绍： Cell Chemical Biology, a Cell Press journal established in 1994 as Chemistry & Biology, focuses on publishing crucial advances in chemical biology research with broad appeal to our diverse community, spanning basic scientists to clinicians. Pioneering investigations at the chemistry-biology interface, the journal fosters collaboration between these disciplines. We encourage submissions providing significant conceptual advancements of broad interest across chemical, biological, clinical, and related fields. Particularly sought are articles utilizing chemical tools to perturb, visualize, and measure biological systems, offering unique insights into molecular mechanisms, disease biology, and therapeutics.