香港儿童 2 型糖尿病患者在确诊后两年的血糖控制情况和微血管并发症。

IF 3.1 4区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Hong Kong Medical Journal Pub Date : 2024-08-01 Epub Date: 2024-08-16 DOI:10.12809/hkmj2210552
W I Yam, S M Y Wong, P T Cheung, E Y W Kwan, Y Y Lam, L M Wong, K L Ng, S W C Wong, C Y Lee, M K Tay, K T Chan, A C C Fu, J Y L Tung, G S W Pang, H C Yau, Q W S See, P W C Lo, S W Y To, H W Yuen, J Y K Chung, E W Y Wong, S W Y Poon, C H Y Lam, S S Y Chan, J H C Tsui, C S Y Chan, B W M But
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引用次数: 0

摘要

导言:2型糖尿病(T2DM)在全球儿童和青少年中越来越常见,香港也不例外。本研究分析了香港儿童T2DM患者在确诊时和确诊后2年的微血管并发症的特征和发病率:所有患者年龄诊断时的血红蛋白A1c(HbA1c)中位数为7.5%(约203人),诊断2年后的血红蛋白A1c中位数为6.5%(约135人);59.3%的患者达到最佳血糖控制水平(HbA1c水平):这些结果凸显了早期诊断和整体管理(包括合并疾病管理)对儿科 T2DM 患者的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glycaemic control and microvascular complications among paediatric type 2 diabetes mellitus patients in Hong Kong at 2 years after diagnosis.

Introduction: Type 2 diabetes mellitus (T2DM) is becoming increasingly common among children and adolescents worldwide, including those in Hong Kong. This study analysed the characteristics and prevalence of microvascular complications among paediatric T2DM patients in Hong Kong at diagnosis and 2 years after diagnosis.

Methods: All patients aged <18 years who had been diagnosed with DM at public hospitals in Hong Kong were recruited into the Hong Kong Childhood Diabetes Registry. Data collected at diagnosis and 2 years after diagnosis were retrospectively retrieved from the Registry for patients diagnosed from 2014 to 2018.

Results: Median haemoglobin A1c (HbA1c) levels were 7.5% (n=203) at diagnosis and 6.5% (n=135) 2 years after diagnosis; 59.3% of patients achieved optimal glycaemic control (HbA1c level <7%) at 2 years. A higher HbA1c level at diagnosis was associated with worse glycaemic control at 2 years (correlation coefficient=0.39; P<0.001). The presence of dyslipidaemia (adjusted odds ratio [aOR]=3.19; P=0.033) and fatty liver (aOR=2.50; P=0.021) at 2 years were associated with suboptimal glycaemic control. Diabetic neuropathy and retinopathy were rare in our cohort, but 18.6% of patients developed microalbuminuria (MA) within 2 years after diagnosis. Patients with MA had a higher HbA1c level at 2 years (median: 7.2% vs 6.4%; P=0.037). Hypertension was a risk factor for MA at 2 years, independent of glycaemic control (aOR=4.61; P=0.008).

Conclusion: These results highlight the importance of early diagnosis and holistic management (including co-morbidity management) for paediatric T2DM patients.

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来源期刊
Hong Kong Medical Journal
Hong Kong Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.50
自引率
14.80%
发文量
117
审稿时长
10 weeks
期刊介绍: The HKMJ is a Hong Kong-based, peer-reviewed, general medical journal which is circulated to 6000 readers, including all members of the HKMA and Fellows of the HKAM. The HKMJ publishes original research papers, review articles, medical practice papers, case reports, editorials, commentaries, book reviews, and letters to the Editor. Topics of interest include all subjects that relate to clinical practice and research in all branches of medicine. The HKMJ welcomes manuscripts from authors, but usually solicits reviews. Proposals for review papers can be sent to the Managing Editor directly. Please refer to the contact information of the Editorial Office.
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