CFTR 与结直肠癌易感性：迫切需要进一步研究。

IF 14.3 1区医学 Q1 ONCOLOGY

Trends in cancer Pub Date : 2024-10-01 Epub Date: 2024-08-14 DOI:10.1016/j.trecan.2024.07.006

S Spelier, S Derksen, R Hofland, J M Beekman, B Yetkin-Arik

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引用次数: 0

摘要

囊性纤维化跨膜传导调节器（CFTR）基因突变会导致囊性纤维化，这是一种以上皮细胞液体分泌异常为特征的多器官疾病。最近的研究描述了 CFTR 功能失常与结肠直肠癌（CRC）易感性增高之间的联系。在此，我们概述了这些联系，并提出了进一步研究的方向。

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查看原文本刊更多论文

CFTR and colorectal cancer susceptibility: an urgent need for further studies.

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene result in cystic fibrosis, a multiorgan disease characterized by aberrant epithelial cell fluid secretion. Recent studies describe a connection between CFTR malfunctioning and a heightened susceptibility to colorectal cancer (CRC). Here, we outline these links and suggest directions for further studies.

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来源期刊

Trends in cancer Medicine-Oncology

CiteScore

28.50

自引率

0.50%

发文量

138

期刊介绍： Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.