一些新合成的4-喹诺酮类化合物对质粒的“固化”。

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy Pub Date : 1988-10-01

L Selan, F Scazzocchio, B Oliva, S Schippa, N Allocati, G Renzini

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引用次数: 0

摘要

萘啶酸和最近合成的两种4-喹诺酮类药物在最低抑制浓度(MIC)的一半或四分之一的浓度下可以消除大肠杆菌中的F'lac和r -质粒。三个质粒中的两个被所有衍生物固化，尽管频率不同。与其他喹诺酮类药物相比，培氟沙星是最有效的化合物，而萘啶酸的活性最低。

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Plasmid "curing" by some recently synthetized 4-quinolone compounds.

Nalidixic acid and two recently synthetized 4-quinolones eliminated F'lac and R-plasmids from E. coli at concentrations of one half or one quarter of the minimum inhibitory concentration (MIC). Two of the three plasmids tested were cured by all derivatives, although with different frequencies. Pefloxacin was the most effective compound compared with the other quinolones and nalidixic acid the least active.

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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

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