新西兰系统性红斑狼疮患者的治疗模式。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2024-10-01 Epub Date: 2024-08-16 DOI:10.1177/09612033241274911
Chunhuan Lao, Philippa Van Dantzig, Nikki Tugnet, Ross Lawrenson, Douglas White
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引用次数: 0

摘要

研究目的本研究旨在探讨奥特亚罗瓦/新西兰系统性红斑狼疮(SLE)的治疗模式:方法:将系统性红斑狼疮患者与配药数据联系起来。按性别、种族、年龄组、社会经济地位和系统性红斑狼疮鉴定年份比较了公共资助的抗疟疾药物、免疫调节剂、生物制剂、糖皮质激素和双膦酸盐的使用情况。使用药物持有率(MPR)对羟氯喹的依从性进行了检查,MPR≥0.8被认为是高依从性:在2631名系统性红斑狼疮患者中,73.8%使用羟氯喹,64.1%使用免疫调节剂/生物制剂,68.0%每天使用5毫克或更多泼尼松至少90天。女性比男性更倾向于使用羟氯喹。亚裔患者的治疗模式与其他种族群体不同,毛利人使用羟氯喹的可能性较低。使用不同治疗方法的患者比例随着年龄的增长而下降。在使用羟氯喹的患者中,54.5%的依从性较高。在 40 岁以上、长期服用泼尼松的患者中,47.3% 使用双膦酸盐,而在 40 岁以下的患者中,这一比例为 17.8%。与社会经济地位较低的患者相比,社会经济地位较高的患者使用双膦酸盐的概率更高:这些患者对羟氯喹的依从性各不相同,男性和毛利人的依从性较低。泼尼松是常用的处方药,可长期使用。40岁以上的患者中有一半同时服用了双磷酸盐。需要开展进一步的研究,以确定系统性红斑狼疮的治疗因性别、种族、年龄和社会经济地位而存在差异的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Treatment patterns in patients with systemic lupus erythematosus in New Zealand.

Objectives: This study aims to explore the treatment pattern of systemic lupus erythematosus (SLE) in Aotearoa/New Zealand.

Methods: SLE patients were linked to the pharmaceutical dispensing data. The use of publicly funded anti-malarials, immunomodulators, biologics, glucocorticoids and bisphosphonates were compared by gender, ethnicity, age group, socioeconomic status and year of SLE identification. Adherence to hydroxychloroquine was examined using the medication possession ratio (MPR), with a MPR of ≥0.8 considered as high adherence.

Results: Of the 2631 SLE patients, 73.8% used hydroxychloroquine, 64.1% used immunomodulators/biologics and 68.0% used 5 mg or more prednisone daily for at least 90 days. Women were more likely to use hydroxychloroquine than men. Asian patients had a different treatment pattern than other ethnic groups, and Māori were less likely to use hydroxychloroquine. The proportions of patients using different treatments decreased with age. Of the patients using hydroxychloroquine, 54.5% had high adherence. For patients over 40 years old and on long term prednisone, 47.3% had bisphosphonates and this figure was 17.8% for patients under the age of 40 years old. Patients with better socioeconomic status had a higher probability of using bisphosphonates than patients with lower socioeconomic status.

Conclusions: Adherence to hydroxychloroquine in these patients varied and was lower in men and in Māori. Prednisone is commonly prescribed and used long term. Half of those over the age of 40 years old co-administered bisphosphonate. Further research is needed to identify the reasons for these discrepancies on SLE treatments by gender, ethnicity, age and socioeconomic status.

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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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