封面内页图片

IF 5.5 1区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
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引用次数: 0

摘要

3,4-二氢喹唑啉框架经常出现在天然产物和生物活性分子中,由于其突出的生物特性,如锥硫蛋白还原酶抑制剂、乙型肝炎病毒抑制活性、抗癌活性等,促使了创新药物的开发。从简单的化学原料通过多组分反应从头组装手性 3,4-二氢喹唑啉类化合物仍存在一些巨大的障碍,而这种方案能够对这些骨架进行多样化和灵活的调节,这正是药物发现所迫切需要的。更多详情请见第 2140-2146 页 Yu 等人的文章。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Inside Cover Picture

Inside Cover Picture

3,4-Dihydroquinazoline frameworks which have frequently been encountered in natural products and bioactive molecules, prompted the development of creative pharmaceuticals owing to their prominent biological properties, such as trypanothione reductase inhibitor, Hepatitis B virus inhibitive activities, anticancer activities, etc. De novo assembling of chiral 3,4-dihydroquinazolines from simple chemical feedstocks via multicomponent reactions remains several great obstacles, and this scenario is capable of the divergent and flexible modulation of these skeletons which is urgently required for drug discovery. More details are discussed in the article by Yu et al. on page 2140—2146.

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来源期刊
Chinese Journal of Chemistry
Chinese Journal of Chemistry 化学-化学综合
CiteScore
8.80
自引率
14.80%
发文量
422
审稿时长
1.7 months
期刊介绍: The Chinese Journal of Chemistry is an international forum for peer-reviewed original research results in all fields of chemistry. Founded in 1983 under the name Acta Chimica Sinica English Edition and renamed in 1990 as Chinese Journal of Chemistry, the journal publishes a stimulating mixture of Accounts, Full Papers, Notes and Communications in English.
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