单容积动态 CT 心肌血流测量技术的再现性:在猪模型中的验证。

IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Negin Hadjiabdolhamid, Yixiao Zhao, Logan Hubbard, Sabee Molloi
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引用次数: 0

摘要

背景:我们对新型低剂量单容积动态计算机断层扫描(CT)心肌血流测量技术的重现性进行了前瞻性评估:我们对新型低剂量单容积动态计算机断层扫描(CT)心肌血流测量技术的可重复性进行了前瞻性评估:方法:对 13 头猪(54.3 ± 12.3 千克)进行了 34 对静息和应激条件下的测量。每只动物采集一或两对数据,每对数据之间延迟 10 分钟。以 5 mL/s 的速度向外周注射对比剂(370 mgI/mL;0.5 mL/kg)和稀释的对比剂/盐水追逐液(0.5 mL/kg;对比剂/盐水的比例为 30:70),然后使用 320 排 CT 扫描仪进行栓剂跟踪和单容积扫描(100 kVp;200 mA)。利用栓剂跟踪和单次容积扫描数据,采用一次通过分析模型得出以 mL/min/g 为单位的灌注量;采用先前验证的最小成本路径技术自动分配左前降支 (LAD)、左环挠 (LCx) 和右冠状动脉 (RCA) 的冠状动脉灌注区域。通过回归分析评估了 LAD、LCx、RCA 和整个心肌内 CT 心肌灌注测量的再现性。结果显示,重复第一次(Pmyo1)和重复第二次(Pmyo2)的心肌灌注测量结果均优于重复第三次(Pmyo3)和重复第三次(Pmyo4):结果:重复的第一次(Pmyo1)和第二次(Pmyo2)单容积 CT 灌注测量值的相关性为 Pmyo2 = 1.01Pmyo1 - 0.03(ρ = 0.96;RMSE = 0.08 mL/min/g;RMSE = 0.07毫升/分钟/克),LAD、LCx 和 RCA 灌注区域的 Preg2 = 0.86Preg1 + 0.13(ρ = 0.87;RMSE = 0.31 毫升/分钟/克;RMSE = 0.29 毫升/分钟/克)。单容积 CT 灌注测量的平均 CTDI 为 10.5 mGy:结论:单容积 CT 血流测量技术只需使用药栓跟踪数据和单次全心容积扫描,就能进行可重复的低剂量心肌灌注测量:单容积 CT 血流测量技术是一种无创工具,可重复测量心肌灌注并提供冠状动脉 CT 血管造影,从而同时对心肌缺血进行解剖学和生理学评估:要点:低剂量单容积动态 CT 心肌血流测量技术具有可重复性。使用单容积 CT 灌注技术可消除运动失准伪影。该技术可对冠状动脉疾病进行解剖学和生理学联合评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Reproducibility of a single-volume dynamic CT myocardial blood flow measurement technique: validation in a swine model.

Reproducibility of a single-volume dynamic CT myocardial blood flow measurement technique: validation in a swine model.

Background: We prospectively assessed the reproducibility of a novel low-dose single-volume dynamic computed tomography (CT) myocardial blood flow measurement technique.

Methods: Thirty-four pairs of measurements were made under rest and stress conditions in 13 swine (54.3 ± 12.3 kg). One or two acquisition pairs were acquired in each animal with a 10-min delay between each pair. Contrast (370 mgI/mL; 0.5 mL/kg) and a diluted contrast/saline chaser (0.5 mL/kg; 30:70 contrast/saline) were injected peripherally at 5 mL/s, followed by bolus tracking and acquisition of a single volume scan (100 kVp; 200 mA) with a 320-slice CT scanner. Bolus tracking and single volume scan data were used to derive perfusion in mL/min/g using a first-pass analysis model; the coronary perfusion territories of the left anterior descending (LAD), left circumflex (LCx), and right coronary artery (RCA) were automatically assigned using a previously validated minimum-cost path technique. The reproducibility of CT myocardial perfusion measurement within the LAD, LCx, RCA, and the whole myocardium was assessed via regression analysis. The average CT dose index (CTDI) of perfusion measurement was recorded.

Results: The repeated first (Pmyo1) and second (Pmyo2) single-volume CT perfusion measurements were related by Pmyo2 = 1.01Pmyo1 - 0.03(ρ = 0.96; RMSE = 0.08 mL/min/g; RMSE = 0.07 mL/min/g) for the whole myocardium, and by Preg2 = 0.86Preg1 + 0.13(ρ = 0.87; RMSE = 0.31 mL/min/g; RMSE = 0.29 mL/min/g) for the LAD, LCx, and RCA perfusion territories. The average CTDI of the single-volume CT perfusion measurement was 10.5 mGy.

Conclusion: The single-volume CT blood flow measurement technique provides reproducible low-dose myocardial perfusion measurement using only bolus tracking data and a single whole-heart volume scan.

Relevance statement: The single-volume CT blood flow measurement technique is a noninvasive tool that reproducibly measures myocardial perfusion and provides coronary CT angiograms, allowing for simultaneous anatomic-physiologic assessment of myocardial ischemia.

Key points: A low-dose single-volume dynamic CT myocardial blood flow measurement technique is reproducible. Motion misregistration artifacts are eliminated using a single-volume CT perfusion technique. This technique enables combined anatomic-physiologic assessment of coronary artery disease.

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来源期刊
European Radiology Experimental
European Radiology Experimental Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
6.70
自引率
2.60%
发文量
56
审稿时长
18 weeks
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