RNA还是DNA?重新审视先天基因组的化学本质

IF 2.1 3区 生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Journal of Molecular Evolution Pub Date : 2024-10-01 Epub Date: 2024-08-15 DOI:10.1007/s00239-024-10194-9
Wolfgang Cottom-Salas, Arturo Becerra, Antonio Lazcano
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引用次数: 0

摘要

了解早期细胞进化的核心问题之一是确定 "原癌基因 "的特征。这包括描述其基因组的化学性质。在这个问题上的分歧包括几种建议,其中包括 AlkB 介导的对烷基化 RNA 分子的甲基化修复可能被解释为噬菌体 RNA 基因组的证据。我们在此介绍基于三级结构系统进化的杯状蛋白超家族的进化分析,其中包括依赖氧的 AlkB 及其同源物。我们的研究结果表明,甲基化 RNA 分子的修复是酶底物模糊的结果,并不一定表明最后的共同祖先具有 RNA 基因组。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

RNA or DNA? Revisiting the Chemical Nature of the Cenancestral Genome.

RNA or DNA? Revisiting the Chemical Nature of the Cenancestral Genome.

One of the central issues in the understanding of early cellular evolution is the characterisation of the cenancestor. This includes the description of the chemical nature of its genome. The disagreements on this question comprise several proposals, including the possibility that AlkB-mediated methylation repair of alkylated RNA molecules may be interpreted as evidence of a cenancestral RNA genome. We present here an evolutionary analysis of the cupin-like protein superfamily based on tertiary structure-based phylogenies that includes the oxygen-dependent AlkB and its homologs. Our results suggest that the repair of methylated RNA molecules is the outcome of the enzyme substrate ambiguity, and doesn´t necessarily indicates that the last common ancestor was endowed with an RNA genome.

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来源期刊
Journal of Molecular Evolution
Journal of Molecular Evolution 生物-进化生物学
CiteScore
5.50
自引率
2.60%
发文量
36
审稿时长
3 months
期刊介绍: Journal of Molecular Evolution covers experimental, computational, and theoretical work aimed at deciphering features of molecular evolution and the processes bearing on these features, from the initial formation of macromolecular systems through their evolution at the molecular level, the co-evolution of their functions in cellular and organismal systems, and their influence on organismal adaptation, speciation, and ecology. Topics addressed include the evolution of informational macromolecules and their relation to more complex levels of biological organization, including populations and taxa, as well as the molecular basis for the evolution of ecological interactions of species and the use of molecular data to infer fundamental processes in evolutionary ecology. This coverage accommodates such subfields as new genome sequences, comparative structural and functional genomics, population genetics, the molecular evolution of development, the evolution of gene regulation and gene interaction networks, and in vitro evolution of DNA and RNA, molecular evolutionary ecology, and the development of methods and theory that enable molecular evolutionary inference, including but not limited to, phylogenetic methods.
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