剖腹产期间母体使用抗生素预防对婴儿肠道微生物组的影响有限

IF 20.6 1区 医学 Q1 MICROBIOLOGY
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引用次数: 0

摘要

接受剖腹产(CS)的孕妇通常会在切开皮肤前接受抗生素治疗,以预防感染。为了研究抗生素的使用时间是否会影响婴儿的肠道微生物组,我们对按计划进行剖宫产的产妇进行了一项随机对照试验(NCT06030713),这些产妇在皮肤切开前或脐带夹闭后接受抗生素治疗。我们在出生后的 8 个时间点对 28 名婴儿的 172 份样本进行了纵向分析,并在 1 个月时对来自 3 个队列的 79 名婴儿进行了横断面分析。虽然没有发现细菌组成、代谢途径、短链脂肪酸和胆汁酸有明显的关联,但我们观察到各组之间在细菌菌株水平和抗生素耐药基因负荷方面存在微妙的差异。相反,喂养方式是影响婴儿微生物组成的主要决定性因素。总之,在分娩过程中使用抗生素对婴儿早期肠道微生物组的影响有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome

Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome

Pregnant women undergoing a cesarean section (CS) typically receive antibiotics prior to skin incision to prevent infections. To investigate if the timing of antibiotics influences the infant gut microbiome, we conducted a randomized controlled trial (NCT06030713) in women delivering via a scheduled CS who received antibiotics either before skin incision or after umbilical cord clamping. We performed a longitudinal analysis on 172 samples from 28 infants at 8 post-birth time points and a cross-sectional analysis at 1 month in 79 infants from 3 cohorts. Although no significant associations with bacterial composition, metabolic pathways, short-chain fatty acids, and bile acids were found, we observed subtle differences between the groups at the bacterial strain level and in the load of antibiotic resistance genes. Rather, feeding mode was a predominant and defining factor impacting infant microbial composition. In conclusion, antibiotic administration during CS has only limited effects on the early-life gut microbiome.

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来源期刊
Cell host & microbe
Cell host & microbe 生物-微生物学
CiteScore
45.10
自引率
1.70%
发文量
201
审稿时长
4-8 weeks
期刊介绍: Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.
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