硫化氢的神经保护信号及其在阿尔茨海默病中的失调

IF 6.9 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current Opinion in Chemical Biology Pub Date : 2024-08-13 DOI:10.1016/j.cbpa.2024.102511

Bindu D. Paul , Andrew A. Pieper

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引用次数: 0

摘要

古老的信使分子硫化氢（H2S）能调节无数的信号级联，并在进化过程中保持不变。虽然 H2S 传统上被认为是一种环境毒素，但它也可以在内源性合成，在一系列生理功能中发挥调节和平衡作用。值得注意的是，H2S 的水平受到严格的生理调控，因为过量或过少都会产生毒性。越来越多的证据表明，H2S 在神经保护和正常认知功能中发挥着关键作用，而在神经退行性疾病中，H2S 的平衡则会失调。在此，我们回顾了 H2S 在阿尔茨海默病（最常见的神经退行性疾病）中发挥的正常神经保护作用。

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Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease

The ancient messenger molecule hydrogen sulfide (H₂S) modulates myriad signaling cascades and has been conserved across evolutionary boundaries. Although traditionally known as an environmental toxin, H₂S is also synthesized endogenously to exert modulatory and homeostatic effects in a broad array of physiologic functions. Notably, H₂S levels are tightly physiologically regulated, as both its excess and paucity can be toxic. Accumulating evidence has revealed pivotal roles for H₂S in neuroprotection and normal cognitive function, and H₂S homeostasis is dysregulated in neurodegenerative conditions. Here, we review the normal neuroprotective roles of H₂S that go awry in Alzheimer's disease, the most common form of neurodegenerative disease.

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来源期刊

Current Opinion in Chemical Biology 生物-生化与分子生物学

CiteScore

13.30

自引率

1.30%

发文量

113

审稿时长

74 days

期刊介绍： COCHBI (Current Opinion in Chemical Biology) is a systematic review journal designed to offer specialists a unique and educational platform. Its goal is to help professionals stay informed about the growing volume of information in the field of Chemical Biology through systematic reviews.