硫化氢的神经保护信号及其在阿尔茨海默病中的失调

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-08-13 DOI:10.1016/j.cbpa.2024.102511

Bindu D. Paul , Andrew A. Pieper

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引用次数: 0

摘要

古老的信使分子硫化氢（H2S）能调节无数的信号级联，并在进化过程中保持不变。虽然 H2S 传统上被认为是一种环境毒素，但它也可以在内源性合成，在一系列生理功能中发挥调节和平衡作用。值得注意的是，H2S 的水平受到严格的生理调控，因为过量或过少都会产生毒性。越来越多的证据表明，H2S 在神经保护和正常认知功能中发挥着关键作用，而在神经退行性疾病中，H2S 的平衡则会失调。在此，我们回顾了 H2S 在阿尔茨海默病（最常见的神经退行性疾病）中发挥的正常神经保护作用。

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Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease

The ancient messenger molecule hydrogen sulfide (H₂S) modulates myriad signaling cascades and has been conserved across evolutionary boundaries. Although traditionally known as an environmental toxin, H₂S is also synthesized endogenously to exert modulatory and homeostatic effects in a broad array of physiologic functions. Notably, H₂S levels are tightly physiologically regulated, as both its excess and paucity can be toxic. Accumulating evidence has revealed pivotal roles for H₂S in neuroprotection and normal cognitive function, and H₂S homeostasis is dysregulated in neurodegenerative conditions. Here, we review the normal neuroprotective roles of H₂S that go awry in Alzheimer's disease, the most common form of neurodegenerative disease.

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.