边缘可切除或局部晚期胰头癌患者血管切除后的生存率:系统综述。

IF 1.1 Q4 GASTROENTEROLOGY & HEPATOLOGY
Menelaos Papakonstantinou, Stylianos Fiflis, Alexandros Giakoustidis, Grigorios Christodoulidis, Athanasia Myriskou, Eleni Louri, Lavrentios Papalavrentios, Vasileios N Papadopoulos, Dimitrios Giakoustidis
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引用次数: 0

摘要

胰腺导管腺癌(PDAC)是侵袭性最强的肿瘤之一,也是导致癌症相关死亡的最常见原因。过去,肿瘤的血管浸润会导致无法切除。但如今,静脉或动脉受累的 PDAC 被归类为边缘可切除(BR)或局部晚期(LA)疾病。带血管切除的胰十二指肠切除术(PD)是一种很有前景的干预措施,旨在完全切除BR和LA-PDAC。本研究旨在评估接受胰十二指肠切除术并进行血管切除的患者与未进行血管切除的患者的总生存率。我们在PubMed上搜索了纳入接受血管切除术的BR或LA-PDAC患者的队列研究。按照系统综述和荟萃分析首选报告项目(PRISMA)清单对检索到的出版物进行了筛选。研究方案已在国际系统综述前瞻性注册中心(PROSPERO)注册。我们的系统综述共纳入了 16 项队列研究。其中14项研究纳入了接受腹腔镜下单纯静脉切除术的PDAC患者。血管切除患者的5年总生存率从8.0%到22.2%不等,标准PD患者的5年总生存率从4.0%到24.3%不等。三个队列包括了接受动脉切除术治疗的动脉和/或静脉受累的PDAC患者。他们的中位总生存期从13.7个月到17.0个月不等,与未接受血管切除术的患者相似。对BR-和LA-PDAC患者进行血管切除的腹膜透析治疗可获得与标准腹膜透析治疗相似的总生存期。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Survival after vascular resections in patients with borderline resectable or locally advanced pancreatic head cancer: A systematic review.

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive tumors, and the most common cause of cancer-related deaths. In the past, vascular infiltration of the tumor rendered the disease unresectable. However, today, venous or arterial involvement of a PDAC is classified as borderline resectable (BR) or locally advanced (LA) disease. Pancreaticoduodenectomy (PD) with vascular resections is a promising intervention intended for complete resection of BR- and LA-PDAC. This study aims to assess the overall survival of patients undergoing PD with vascular resections, compared to those without. A PubMed search was conducted for cohort studies that included patients with BR- or LA-PDAC treated with vascular resections. The retrieved publications were screened following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. The study protocol was registered at the International Prospective Register for Systematic Reviews (PROSPERO). Sixteen cohort studies were included in our systematic review. Fourteen of them included patients undergoing PD with venous-only resections for PDAC. The 5-year overall survival rates ranged from 8.0% to 22.2% for vascular resection patients, and 4.0% to 24.3% for standard PD patients. Three cohorts included patients with PDAC and arterial and/or venous involvement who were treated with arterial resections. Their median overall survival ranged from 13.7 to 17.0 months, similar to that of patients who did not undergo vascular resections. PD with vascular resections in patients with BR- and LA-PDAC could lead to similar overall survival to that after standard PD.

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