斑片状脱发患者穴内注射维生素 D3 与穴内注射曲安奈德:临床与皮肤镜对比研究。

IF 1.2 4区 医学 Q3 DERMATOLOGY
Maha H Ragaie, Shimaa E Mohammed, Shimaa S Shehata
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引用次数: 0

摘要

背景:斑秃(AA)是一种常见的自身免疫性T细胞介导的非瘢痕性脱发。目的:比较鞘内注射维生素 D3 和鞘内注射曲安奈德治疗斑片状脱发的疗效:这项临床研究以40名成年斑片状脱发患者为对象,将患者分为两组。第一组 20 名患者每 4 周接受 1 毫升维生素 D3(胆钙化醇水制剂 200 000 IU/2 毫升)的局部注射,最多 3 次。第二组有 20 名患者,他们每 4 周接受一次 1 毫升 40 毫克/毫升的曲安奈德内注射,最多三次。在基线、每次疗程和最后一次疗程后的 3 个月内,对患者进行了临床和三腔镜评估:结果:在临床改善程度方面,两个研究组之间没有明显的统计学差异(P = .8)。在疗程结束后和 3 个月的随访中,两组患者的 AA 特异性三腔镜体征均有明显减少,但无统计学差异。此外,在不良反应方面,两组之间也存在统计学意义上的显著差异,患者对点内注射维生素 D3 的满意度明显更高:结论:局部注射维生素 D3 是治疗斑片状 AA 的一种有效、简单、安全、廉价的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intralesional vitamin D3 versus intralesional triamcinolone acetonoid in patchy alopecia areata: a comparative clinical and dermoscopic study.

Background: Alopecia areata (AA) is a common autoimmune T-cell mediated non-scarring, form of hair loss. It affects people of all ages and sexes.

Aim: To compare the efficacy of intralesional vitamin D3 injection versus that of intralesional triamcinolone acetonide in the treatment of patchy alopecia areata.

Patients and methods: This clinical study was carried on 40 adult patients with patchy alopecia areata, the patients were categorized into two groups. Group I involved 20 patients who received 1 ml of intralesional injection of vitamin D3 (cholecalciferol aqueous preparation 200 000 IU/2 ml) every 4 weeks for a maximum of three sessions. Group II involved 20 patients who received 1 ml of intralesional injection of triamcinolone acetonide 40 mg/mL every 4 weeks for a maximum of three sessions. Clinical and trichoscopic evaluations were done at the baseline, each session and for 3 months after the last session.

Results: There was no statistically significant difference between the two studied groups regarding the degree of clinical improvement (p = .8). A statistically significant reduction in AA specific trichoscopic signs was detected at the end of the sessions and after 3 months of follow-up in both groups, without any statistically significant difference between them. Also a statistically significant difference was found between both groups regarding the reported adverse effects with a significant better patient satisfaction encountered toward the intralesional vitamin D3 injection.

Conclusion: Intralesional vitamin D3 is a promising effective, simple, safe, and inexpensive, therapeutic modality for patchy AA.

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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: A unique journal that focuses on the application of cosmetic laser and light therapies on the skin. The Journal of Cosmetic & Laser Therapy provides a forum for stimulating and up-to-date studies demonstrating the wide range of therapeutic options for clinicians and surgeons involved in cosmetic and dermatological treatment. The journal is aimed at dermatologists, cosmetic surgeons, plastic and facial plastic surgeons, oculoplastic surgeons and all those interested in the rapidly expanding field of cosmetic and laser therapy. Features include: -Cosmetic surgery, including facial rejuvenation, hair removal and skin resurfacing -Use of lasers and other light sources for cosmetic and dermatological treatment -Applications of peeling agents, fillers, injectables, implants and other cosmetic modalities -Topical treatments -Practical tips and safety issues
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