作为多功能纳米酶的新兴纳米材料:生物医学研究的新维度。

IF 8.6 2区 化学 Q1 Chemistry
Evin Jacob, Denno Mathew, Libina Benny, Anitha Varghese
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引用次数: 0

摘要

多功能纳米材料的仿酶特性提出了一类新材料,即纳米酶(ornanozymes)。它们是通过对纳米材料进行功能化处理而制造出的人造酶,可产生模仿酶功能的活性位点。这些材料从金属和氧化物到无机纳米粒子都具有类似酶的内在特性。纳米酶可以很好地解决天然酶的高成本、低稳定性、难以分离、可重复使用和储存等问题。自 2007 年以来,已有 100 多种纳米酶被报道,它们模仿过氧化物酶、氧化酶、过氧化氢酶、蛋白酶、核酸酶、水解酶、超氧化物歧化酶等酶。此外,一些纳米酶还具有多酶特性。利用纳米酶的化学、光学和理化特性,已有大量应用报道。本综述将重点介绍已报道的由多种材料制成的纳米酶,以及它们的酶模拟活性,其中涉及对金属纳米颗粒(NPs)、金属氧化物 NPs、金属有机框架(MOF)、共价有机框架(COF)和碳基 NPs 等材料的调整。此外,还详细讨论了纳米酶在生物医学研究中的各种应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Emerging Nanomaterials as Versatile Nanozymes: A New Dimension in Biomedical Research

Emerging Nanomaterials as Versatile Nanozymes: A New Dimension in Biomedical Research

The enzyme-mimicking nature of versatile nanomaterials proposes a new class of materials categorized as nano-enzymes, ornanozymes. They are artificial enzymes fabricated by functionalizing nanomaterials to generate active sites that can mimic enzyme-like functions. Materials extend from metals and oxides to inorganic nanoparticles possessing intrinsic enzyme-like properties. High cost, low stability, difficulty in separation, reusability, and storage issues of natural enzymes can be well addressed by nanozymes. Since 2007, more than 100 nanozymes have been reported that mimic enzymes like peroxidase, oxidase, catalase, protease, nuclease, hydrolase, superoxide dismutase, etc. In addition, several nanozymes can also exhibit multi-enzyme properties. Vast applications have been reported by exploiting the chemical, optical, and physiochemical properties offered by nanozymes. This review focuses on the reported nanozymes fabricated from a variety of materials along with their enzyme-mimicking activity involving tuning of materials such as metal nanoparticles (NPs), metal-oxide NPs, metal–organic framework (MOF), covalent organic framework (COF), and carbon-based NPs. Furthermore, diverse applications of nanozymes in biomedical research are discussed in detail.

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来源期刊
Topics in Current Chemistry
Topics in Current Chemistry 化学-化学综合
CiteScore
11.70
自引率
1.20%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Topics in Current Chemistry provides in-depth analyses and forward-thinking perspectives on the latest advancements in chemical research. This renowned journal encompasses various domains within chemical science and their intersections with biology, medicine, physics, and materials science. Each collection within the journal aims to offer a comprehensive understanding, accessible to both academic and industrial readers, of emerging research in an area that captivates a broader scientific community. In essence, Topics in Current Chemistry illuminates cutting-edge chemical research, fosters interdisciplinary collaboration, and facilitates knowledge-sharing among diverse scientific audiences.
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