Carolina H Girotto, Diego A Ospina-Argüelles, Francisco J Teixeira-Neto, Paulo V Assis-Vieira, Alessandro R C Martins, Carolyn Kerr
{"title":"用固定潮气量为体重较小的猫和狗通气时的死腔容积。","authors":"Carolina H Girotto, Diego A Ospina-Argüelles, Francisco J Teixeira-Neto, Paulo V Assis-Vieira, Alessandro R C Martins, Carolyn Kerr","doi":"10.1016/j.vaa.2024.06.009","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To compare the portion of tidal volume (V<sub>T</sub>) ventilating dead space volumes in nonbrachycephalic cats and dogs with small body mass receiving volume-controlled ventilation (VCV) with a fixed V<sub>T</sub>.</p><p><strong>Study design: </strong>Prospective, experimental study.</p><p><strong>Animals: </strong>A group of eight healthy adult cats and dogs [ideal body weight (IBW): 3.0 ± 0.5 and 3.8 ± 1.1 kg, respectively].</p><p><strong>Methods: </strong>Anesthetized cats and dogs received VCV with a 12 mL kg<sup>-1</sup> V<sub>T</sub> (inspiratory pause ≥ 0.5 seconds). Respiratory rate (f<sub>R</sub>) was adjusted to maintain normocapnia. Airway dead space (V<sub>Daw</sub>) and alveolar tidal volume (V<sub>Talv</sub>) were measured by volumetric capnography. Physiological dead space (V<sub>Dphys</sub>) and V<sub>Dphys</sub>/V<sub>T</sub> ratio were calculated using the Bohr-Enghoff method. Data recorded before surgery were compared by an unpaired t-test or Mann-Whitney U test (p < 0.05 considered significant).</p><p><strong>Results: </strong>The IBW (p = 0.07), PaCO<sub>2</sub> (p = 0.40) and expired V<sub>T</sub> [V<sub>T(exp)</sub>] (p = 0.77) did not differ significantly between species. The V<sub>Daw</sub> (mL kg<sup>-1</sup>) was lower in cats (3.7 ± 0.4) than in dogs (7.7 ± 0.9) (p < 0.0001). The V<sub>Talv</sub> (mL kg<sup>-1</sup>) was larger in cats (8.3 ± 0.7) than in dogs (4.3 ± 0.7) (p < 0.0001). Cats presented a smaller V<sub>Dphys</sub>/V<sub>T</sub> ratio (0.33 ± 0.03) and V<sub>Dphys</sub> (4.0 ± 0.3 mL kg<sup>-1</sup>) than dogs (V<sub>Dphys</sub>/V<sub>T</sub>: 0.60 ± 0.09; V<sub>Dphys</sub>: 7.2 ± 1.4 mL kg<sup>-1</sup>) (p < 0.0001). The f<sub>R</sub> and minute ventilation (V<sub>T(exp)</sub> × f<sub>R</sub>) were lower in cats than in dogs (p = 0.048 and p = 0.038, respectively).</p><p><strong>Conclusions and clinical relevance: </strong>A fixed V<sub>T</sub> results in more effective ventilation in cats than in dogs with small body mass because of species-specific differences in and V<sub>Daw</sub> and V<sub>Dphys</sub>. Because of the smaller V<sub>Daw</sub> and V<sub>Dphys</sub> in cats than in dogs, a lower f<sub>R</sub> is required to maintain normocapnia in cats.</p>","PeriodicalId":23626,"journal":{"name":"Veterinary anaesthesia and analgesia","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dead space volumes in cats and dogs with small body mass ventilated with a fixed tidal volume.\",\"authors\":\"Carolina H Girotto, Diego A Ospina-Argüelles, Francisco J Teixeira-Neto, Paulo V Assis-Vieira, Alessandro R C Martins, Carolyn Kerr\",\"doi\":\"10.1016/j.vaa.2024.06.009\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To compare the portion of tidal volume (V<sub>T</sub>) ventilating dead space volumes in nonbrachycephalic cats and dogs with small body mass receiving volume-controlled ventilation (VCV) with a fixed V<sub>T</sub>.</p><p><strong>Study design: </strong>Prospective, experimental study.</p><p><strong>Animals: </strong>A group of eight healthy adult cats and dogs [ideal body weight (IBW): 3.0 ± 0.5 and 3.8 ± 1.1 kg, respectively].</p><p><strong>Methods: </strong>Anesthetized cats and dogs received VCV with a 12 mL kg<sup>-1</sup> V<sub>T</sub> (inspiratory pause ≥ 0.5 seconds). Respiratory rate (f<sub>R</sub>) was adjusted to maintain normocapnia. Airway dead space (V<sub>Daw</sub>) and alveolar tidal volume (V<sub>Talv</sub>) were measured by volumetric capnography. Physiological dead space (V<sub>Dphys</sub>) and V<sub>Dphys</sub>/V<sub>T</sub> ratio were calculated using the Bohr-Enghoff method. Data recorded before surgery were compared by an unpaired t-test or Mann-Whitney U test (p < 0.05 considered significant).</p><p><strong>Results: </strong>The IBW (p = 0.07), PaCO<sub>2</sub> (p = 0.40) and expired V<sub>T</sub> [V<sub>T(exp)</sub>] (p = 0.77) did not differ significantly between species. The V<sub>Daw</sub> (mL kg<sup>-1</sup>) was lower in cats (3.7 ± 0.4) than in dogs (7.7 ± 0.9) (p < 0.0001). The V<sub>Talv</sub> (mL kg<sup>-1</sup>) was larger in cats (8.3 ± 0.7) than in dogs (4.3 ± 0.7) (p < 0.0001). Cats presented a smaller V<sub>Dphys</sub>/V<sub>T</sub> ratio (0.33 ± 0.03) and V<sub>Dphys</sub> (4.0 ± 0.3 mL kg<sup>-1</sup>) than dogs (V<sub>Dphys</sub>/V<sub>T</sub>: 0.60 ± 0.09; V<sub>Dphys</sub>: 7.2 ± 1.4 mL kg<sup>-1</sup>) (p < 0.0001). The f<sub>R</sub> and minute ventilation (V<sub>T(exp)</sub> × f<sub>R</sub>) were lower in cats than in dogs (p = 0.048 and p = 0.038, respectively).</p><p><strong>Conclusions and clinical relevance: </strong>A fixed V<sub>T</sub> results in more effective ventilation in cats than in dogs with small body mass because of species-specific differences in and V<sub>Daw</sub> and V<sub>Dphys</sub>. Because of the smaller V<sub>Daw</sub> and V<sub>Dphys</sub> in cats than in dogs, a lower f<sub>R</sub> is required to maintain normocapnia in cats.</p>\",\"PeriodicalId\":23626,\"journal\":{\"name\":\"Veterinary anaesthesia and analgesia\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2024-06-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary anaesthesia and analgesia\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1016/j.vaa.2024.06.009\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary anaesthesia and analgesia","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1016/j.vaa.2024.06.009","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Dead space volumes in cats and dogs with small body mass ventilated with a fixed tidal volume.
Objective: To compare the portion of tidal volume (VT) ventilating dead space volumes in nonbrachycephalic cats and dogs with small body mass receiving volume-controlled ventilation (VCV) with a fixed VT.
Study design: Prospective, experimental study.
Animals: A group of eight healthy adult cats and dogs [ideal body weight (IBW): 3.0 ± 0.5 and 3.8 ± 1.1 kg, respectively].
Methods: Anesthetized cats and dogs received VCV with a 12 mL kg-1 VT (inspiratory pause ≥ 0.5 seconds). Respiratory rate (fR) was adjusted to maintain normocapnia. Airway dead space (VDaw) and alveolar tidal volume (VTalv) were measured by volumetric capnography. Physiological dead space (VDphys) and VDphys/VT ratio were calculated using the Bohr-Enghoff method. Data recorded before surgery were compared by an unpaired t-test or Mann-Whitney U test (p < 0.05 considered significant).
Results: The IBW (p = 0.07), PaCO2 (p = 0.40) and expired VT [VT(exp)] (p = 0.77) did not differ significantly between species. The VDaw (mL kg-1) was lower in cats (3.7 ± 0.4) than in dogs (7.7 ± 0.9) (p < 0.0001). The VTalv (mL kg-1) was larger in cats (8.3 ± 0.7) than in dogs (4.3 ± 0.7) (p < 0.0001). Cats presented a smaller VDphys/VT ratio (0.33 ± 0.03) and VDphys (4.0 ± 0.3 mL kg-1) than dogs (VDphys/VT: 0.60 ± 0.09; VDphys: 7.2 ± 1.4 mL kg-1) (p < 0.0001). The fR and minute ventilation (VT(exp) × fR) were lower in cats than in dogs (p = 0.048 and p = 0.038, respectively).
Conclusions and clinical relevance: A fixed VT results in more effective ventilation in cats than in dogs with small body mass because of species-specific differences in and VDaw and VDphys. Because of the smaller VDaw and VDphys in cats than in dogs, a lower fR is required to maintain normocapnia in cats.
期刊介绍：
Veterinary Anaesthesia and Analgesia is the official journal of the Association of Veterinary Anaesthetists, the American College of Veterinary Anesthesia and Analgesia and the European College of Veterinary Anaesthesia and Analgesia. Its purpose is the publication of original, peer reviewed articles covering all branches of anaesthesia and the relief of pain in animals. Articles concerned with the following subjects related to anaesthesia and analgesia are also welcome:
the basic sciences;
pathophysiology of disease as it relates to anaesthetic management
equipment
intensive care
chemical restraint of animals including laboratory animals, wildlife and exotic animals
welfare issues associated with pain and distress
education in veterinary anaesthesia and analgesia.
Review articles, special articles, and historical notes will also be published, along with editorials, case reports in the form of letters to the editor, and book reviews. There is also an active correspondence section.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
