创伤后干预:儿童-家长心理治疗可降低小儿表观遗传学年龄加速。

IF 4.8 1区 心理学 Q1 PSYCHOLOGY, MULTIDISCIPLINARY
Psychological Science Pub Date : 2024-09-01 Epub Date: 2024-08-14 DOI:10.1177/09567976241260247
Alexandra D W Sullivan, Sarah M Merrill, Chaini Konwar, Michael Coccia, Luisa Rivera, Julia L MacIsaac, Alicia F Lieberman, Michael S Kobor, Nicole R Bush
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引用次数: 0

摘要

早年的生活逆境会增加出现健康问题的风险。支持保护性和响应性护理的干预措施为减轻逆境引起的压力敏感生物标志物的变化提供了一种可行的方法。本研究测试了在有创伤史的儿童样本中,参与循证的双亲心理社会干预--儿童-父母心理治疗(CPP)是否与降低表观遗传年龄加速度有关,表观遗传年龄加速度是对创伤敏感的生物衰老加速标志物,与日后的健康损害有关。在这项准实验、重复测量研究中,我们对接受 CPP 治疗的低收入儿童样本(n = 45;年龄范围 = 2-6岁;76% 拉丁裔)与加权、倾向匹配的社区比较样本(n = 110;年龄范围 = 3-6岁;40% 拉丁裔)在基线和干预后的表观遗传年龄加速度进行了比较。各组的基线表观遗传年龄加速度相同。然而,治疗后,治疗组的表观遗传年龄加速度低于匹配的社区样本。研究结果凸显了通过对受创伤儿童进行社会心理干预来改善其生物加速衰老的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Intervening After Trauma: Child-Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration.

Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child-parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (n = 45; age range = 2-6 years; 76% Latino) compared with a weighted, propensity-matched community-comparison sample (n = 110; age range = 3-6 years; 40% Latino). Baseline epigenetic age acceleration was equivalent across groups. However, posttreatment, epigenetic age acceleration in the treatment group was lower than in the matched community sample. Findings highlight the potential for a dyadic psychosocial intervention to ameliorate accelerated biological aging in trauma-exposed children.

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来源期刊
Psychological Science
Psychological Science PSYCHOLOGY, MULTIDISCIPLINARY-
CiteScore
13.30
自引率
0.00%
发文量
156
期刊介绍: Psychological Science, the flagship journal of The Association for Psychological Science (previously the American Psychological Society), is a leading publication in the field with a citation ranking/impact factor among the top ten worldwide. It publishes authoritative articles covering various domains of psychological science, including brain and behavior, clinical science, cognition, learning and memory, social psychology, and developmental psychology. In addition to full-length articles, the journal features summaries of new research developments and discussions on psychological issues in government and public affairs. "Psychological Science" is published twelve times annually.
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