Alexandra D W Sullivan, Sarah M Merrill, Chaini Konwar, Michael Coccia, Luisa Rivera, Julia L MacIsaac, Alicia F Lieberman, Michael S Kobor, Nicole R Bush
{"title":"创伤后干预:儿童-家长心理治疗可降低小儿表观遗传学年龄加速。","authors":"Alexandra D W Sullivan, Sarah M Merrill, Chaini Konwar, Michael Coccia, Luisa Rivera, Julia L MacIsaac, Alicia F Lieberman, Michael S Kobor, Nicole R Bush","doi":"10.1177/09567976241260247","DOIUrl":null,"url":null,"abstract":"<p><p>Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child-parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (<i>n</i> = 45; age range = 2-6 years; 76% Latino) compared with a weighted, propensity-matched community-comparison sample (<i>n</i> = 110; age range = 3-6 years; 40% Latino). Baseline epigenetic age acceleration was equivalent across groups. However, posttreatment, epigenetic age acceleration in the treatment group was lower than in the matched community sample. Findings highlight the potential for a dyadic psychosocial intervention to ameliorate accelerated biological aging in trauma-exposed children.</p>","PeriodicalId":20745,"journal":{"name":"Psychological Science","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Intervening After Trauma: Child-Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration.\",\"authors\":\"Alexandra D W Sullivan, Sarah M Merrill, Chaini Konwar, Michael Coccia, Luisa Rivera, Julia L MacIsaac, Alicia F Lieberman, Michael S Kobor, Nicole R Bush\",\"doi\":\"10.1177/09567976241260247\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child-parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (<i>n</i> = 45; age range = 2-6 years; 76% Latino) compared with a weighted, propensity-matched community-comparison sample (<i>n</i> = 110; age range = 3-6 years; 40% Latino). Baseline epigenetic age acceleration was equivalent across groups. However, posttreatment, epigenetic age acceleration in the treatment group was lower than in the matched community sample. Findings highlight the potential for a dyadic psychosocial intervention to ameliorate accelerated biological aging in trauma-exposed children.</p>\",\"PeriodicalId\":20745,\"journal\":{\"name\":\"Psychological Science\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Psychological Science\",\"FirstCategoryId\":\"102\",\"ListUrlMain\":\"https://doi.org/10.1177/09567976241260247\",\"RegionNum\":1,\"RegionCategory\":\"心理学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHOLOGY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychological Science","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1177/09567976241260247","RegionNum":1,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/14 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"PSYCHOLOGY, MULTIDISCIPLINARY","Score":null,"Total":0}
Intervening After Trauma: Child-Parent Psychotherapy Treatment Is Associated With Lower Pediatric Epigenetic Age Acceleration.
Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child-parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (n = 45; age range = 2-6 years; 76% Latino) compared with a weighted, propensity-matched community-comparison sample (n = 110; age range = 3-6 years; 40% Latino). Baseline epigenetic age acceleration was equivalent across groups. However, posttreatment, epigenetic age acceleration in the treatment group was lower than in the matched community sample. Findings highlight the potential for a dyadic psychosocial intervention to ameliorate accelerated biological aging in trauma-exposed children.
期刊介绍:
Psychological Science, the flagship journal of The Association for Psychological Science (previously the American Psychological Society), is a leading publication in the field with a citation ranking/impact factor among the top ten worldwide. It publishes authoritative articles covering various domains of psychological science, including brain and behavior, clinical science, cognition, learning and memory, social psychology, and developmental psychology. In addition to full-length articles, the journal features summaries of new research developments and discussions on psychological issues in government and public affairs. "Psychological Science" is published twelve times annually.