联合检测特异性免疫球蛋白 E、白细胞介素-6 和调节性 T 细胞对预测嗜酸性粒细胞慢性鼻炎和鼻息肉患者术后复发风险的价值。

IF 2 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Medical Biochemistry Pub Date : 2024-06-15 DOI:10.5937/jomb0-48780

Xudong Gao, Jin Zhang, An Li, Yu Ding, Bo Zhao, Yujuan Wang

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引用次数: 0

摘要

研究背景目的：探讨特异性免疫球蛋白E（sIgE）、白细胞介素-6（IL-6）和调节性T细胞（Treg）对嗜酸性慢性鼻炎伴鼻息肉（EcRswNP）患者术后复发风险的预测价值：选取2019年1月至2021年12月在我院就诊的198例EcRswNP患者作为研究对象。所有患者均接受了功能性内窥镜鼻窦手术。根据随访一年后的复发情况，将患者分为复发组（RG，n = 48）和未复发组（NRG，n = 150）。分析了 EcRswNP 术后复发的相关因素。采用 ROC 分析了 sIgE、IL-6 和 Treg 对预测 EcRswNP 患者术后复发的危险性：结果：RG的哮喘患者比例、鼻塞VAS评分和外周血Eos%含量均高于NRG，组织Neu%和外周血Neu%水平低于NRGp（P均<0.05）。RG的血清sIgE和血清IL6高于NRG，而外周血Treg水平低于NRG（P均<0.05）。逻辑回归分析显示，高水平的血清sIgE、血清IL-6和低水平的Treg是术后复发的风险因素（P＜0.05）。ROC显示，外周血sIgE水平、IL-6和Treg水平单独预测EcRswNP患者术后复发危险的AUC分别为0.786、0.707和0.636（均P < 0.05）；外周血sIgE、IL-6和Treg水平联合预测EcRswNP患者术后复发危险性的AUC为0.973，表明联合预测的疗效超过单一预测（P < 0.05）：EcRswNP患者术前高水平的sIgE、IL6和低水平的Treg会增加术后复发的风险，是影响术后复发的危险因素，这三个指标对预测EcRswNP患者术后复发有很好的预测价值，三个指标联合预测术后复发有更好的价值。

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The value of combined detection of specific immunoglobulin E, interleukin-6 and regulatory T cells in predicting the risk of postoperative recurrence in patients with eosinophilic chronic rhinosinusitis and nasal polyps.

Background: To investigate the predictive value of specific immunoglobulin E (sIgE), interleukin-6 (IL-6) and regulatory T cells (Treg) on the risk of postoperative recurrence in patients with eosinophilic Chronic rhinosinusitis with nasal polyps (EcRswNP).

Methods: A total of 198 patients with EcRswNP collected to our Hospital from January 2019 to December 2021 were selected as the research subjects. All patients underwent functional endoscopic sinus surgery. The patients were selected to recurrence group (RG, n = 48) and nonrecurrence group (NRG, n = 150) on the basis of the recurrence after 1 year of follow-up. The related factors of postoperative recurrence of EcRswNP were analyzed. The ROC was used to analyze the dangerous of sIgE, IL-6 and Treg in predicting postoperative recurrence of EcRswNP patients.

Results: The proportion of asthma patients, nasal congestion VAS score, and peripheral blood Eos% content in the RG exceeded that in the NRG, and the Organization Neu % and peripheral blood Neu% levels were less than those in the NRGp (P all < 0.05). The serum sIgE and serum IL6 in the RG were higher than those in the NRG, while the level of peripheral blood Treg was lower than that in the NRG (P < 0.05). Logistic regression analysis showed that high levels of serum sIgE, serum IL-6 and low Treg levels were risk factors for postoperative recurrence (P < 0.05). ROC showed that the AUC of peripheral blood sIgE level, IL-6 and Treg levels alone in predicting the dangerous of postoperative recurrence in patients with EcRswNP were 0.786, 0.707 and 0.636, respectively (all P < 0.05); The AUC of combined prediction of peripheral blood sIgE, IL-6 and Treg levels for postoperative recurrence dangerous in patients with EcRswNP was 0.973, indicating that the efficacy of jointed prediction was exceed than that of single prediction (P < 0.05).

Conclusions: The high levels of sIgE, IL6 and low Treg levels in patients with EcRswNP before operation will increase the risk of postoperative recurrence, which is a risk factor affecting postoperative recurrence, and the three indicators have good predictive value for predicting postoperative recurrence in patients with EcRswNP, and the combination of the three indicators has better value in predicting postoperative recurrence.

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来源期刊

Journal of Medical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

3.00

自引率

12.00%

发文量

审稿时长

>12 weeks

期刊介绍： The JOURNAL OF MEDICAL BIOCHEMISTRY (J MED BIOCHEM) is the official journal of the Society of Medical Biochemists of Serbia with international peer-review. Papers are independently reviewed by at least two reviewers selected by the Editors as Blind Peer Reviews. The Journal of Medical Biochemistry is published quarterly. The Journal publishes original scientific and specialized articles on all aspects of clinical and medical biochemistry, molecular medicine, clinical hematology and coagulation, clinical immunology and autoimmunity, clinical microbiology, virology, clinical genomics and molecular biology, genetic epidemiology, drug measurement, evaluation of diagnostic markers, new reagents and laboratory equipment, reference materials and methods, reference values, laboratory organization, automation, quality control, clinical metrology, all related scientific disciplines where chemistry, biochemistry, molecular biology and immunochemistry deal with the study of normal and pathologic processes in human beings.