在治疗患有或未患有注意力缺陷多动障碍的神经性贪食症和神经性厌食症患者时使用兴奋剂药物:系统综述。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Mark L. Vickers , Hong Yin Chan , Stephen Elliott , Sarangan Ketheesan , Vinay Ramineni , Lars Eriksson , Kirsten McMahon , Belinda Oddy , James G. Scott
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引用次数: 0

摘要

目的有注意力问题的人患饮食失调症的风险更高。本文旨在系统回顾和综合现有证据,说明兴奋剂药物在治疗神经性贪食症(BN)或神经性厌食症(AN)患者(无论是否合并注意力缺陷多动障碍(ADHD))方面的作用:方法:根据《系统综述和元分析首选报告项目》(PRISMA)指南进行系统综述。综述方案已在开放科学框架(OSF)注册中心注册,并使用乔安娜-布里格斯研究所(JBI)的批判性评估工具对文献进行了批判性评估:有 13 篇文章符合纳入标准,其中包括 2 项准实验研究、1 项随机对照试验、4 个病例系列和 6 个病例报告。研究中纳入了 26 个病例,病例系列/报告中纳入了 32 个病例。只有一份病例报告中的两个病例被诊断为 AN,其余病例被诊断为 BN。兴奋剂包括甲基苯丙胺、利眠宁、哌醋甲酯、硫酸右旋苯丙胺和混合苯丙胺盐。据报告,几乎所有 BN 病例的进食障碍症状都有所减轻。不良反应的发生率很高,包括体重下降、食欲下降、心动过速、口干、疲劳、失眠、烦躁不安、恶心、磨牙、头痛、心悸、血压变化、易怒、焦虑、情绪低落和全身湿疹:目前没有足够的证据支持使用兴奋剂药物治疗 BN 或 AN 症状。作者建议考虑对 BN 患者进行多动症筛查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stimulant medications in the management of bulimia nervosa and anorexia nervosa in patients with and without comorbid attention deficit hyperactivity disorder: A systematic review

Objective

People with attentional problems are at increased risk of eating disorders. This paper aimed to systematically review and synthesize the existing evidence on stimulant medication in the management of patients with bulimia nervosa (BN) or anorexia nervosa (AN) with or without comorbid attention deficit hyperactivity disorder (ADHD).

Method

A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A protocol for the review was registered with Open Science Framework (OSF) Registry and critical appraisal of the literature was conducted using Joanna Briggs Institute (JBI) Critical Appraisal Tools.

Results

Thirteen articles met inclusion criteria including two quasi-experimental studies, one randomized controlled trial, four case series, and six case reports. 26 cases were included from studies and 32 from case series/reports. Only two cases from a single case report had a diagnosis of AN, while the remainder had BN. Stimulants included methylamphetamine, lisdexamfetamine, methylphenidate, dextroamphetamine sulphate and mixed amphetamine salt. In nearly all cases of BN there were reported reductions in eating disorder symptoms. The rates of adverse effects were high and included weight loss, decreased appetite, tachycardia, dry mouth, fatigue, insomnia, restlessness, nausea, bruxism, headache, palpitations, blood pressure changes, irritability, anxiety, depressed mood, and diaphoresis.

Conclusion

There is currently insufficient evidence to support the use of stimulant medications to treat symptoms of BN or AN. The authors recommend considering screening patients with BN for ADHD.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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