用于抗菌的有机-无机混合铜钴络合物。

IF 2.5 Q3 CELL BIOLOGY
Suhailah S Al-Jameel, Ibtisam M Ababutain, Azzah I Alghamdi, Amor Ben-Ali, Aml H Al-Nasir, Asayel H Alqhtani, Latifah K Aldewely, Mariam M Alhassan, Reem E Bakhurji, Wasan M AlGhamdi, Rana A Alzahrani, Israa A Alrabghi
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引用次数: 0

摘要

背景/目的:从莪术植物中提取的天然酚类化学物质姜黄素(CUR)具有多种生物作用,包括抗炎、抗菌、抗氧化和抗癌活性。众所周知,姜黄素由于疏水性、肠道吸收差和新陈代谢快,其生物利用度受到限制。为了提高这些生物活性分子的生物效应,有必要同时提高它们的生物利用度和在水中的溶解度。目的:本研究旨在合成和表征铜和钴的有机-无机杂化配合物,并评估它们对一系列病原微生物的抗菌潜力:方法:将姜黄素与一水醋酸铜混合,合成金属姜黄素复合物(Cu-CUR 和 Co-CUR)。分离出固体残留物,过滤并在烘箱中干燥。X 射线衍射分析用于确定所制备样品的结构和相位。使用岛津 2200 模块记录了傅立叶变换红外光谱。评估了所制备复合物对四种细菌菌株和两种白色念珠菌的抗菌活性。将化学材料溶于二甲基亚砜(DMSO)中,最终浓度为 20%,然后在 37°C 下培养 24 小时。结果表明,制备的复合物对测试微生物具有抗菌活性:研究比较了制备的铜和钴复合物与纯姜黄素的粉末 X 射线衍射(XRD)图,发现了新的等结构复合物。傅立叶变换红外光谱分析显示,Cu-CUR 和 Co-CUR 复合物对微生物的抑制效果各不相同,其中 Co-CUR 的抑制效果更好。该结果与之前的研究结果一致,即钴姜黄素复合物对各种细菌属有效,抑制活性因微生物的种类和菌株而异:在室温下合成的姜黄素铜钴复合物具有很高的结晶度和抗菌活性。铜钴姜黄素复合物具有卓越的抗菌潜力,在抑制微生物方面优于纯姜黄素。要了解它们与细菌和真菌的相互作用机制,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hybrid Organic-Inorganic Copper and Cobalt Complexes for Antimicrobial Potential Applications.

Background/aims: The naturally occurring phenolic chemical curcumin (CUR), which was derived from the Curcuma longa plant, has a variety of biological actions, including anti-inflammatory, antimicrobial, antioxidant, and anticancer activities. Curcumin is known for its restricted bioavailability due to its hydrophobicity, poor intestinal absorption, and quick metabolism. To boost the biological effects of these bioactive molecules, it is necessary to raise both their bioavailability and their solubility in water. Aim: The aim of this study is to synthesize and characterize hybrid organic-inorganic complexes of copper and cobalt, and to evaluate their antimicrobial potential against a range of pathogenic microorganisms.

Methods: The synthesis of metal curcumin complexes (Cu-CUR and Co-CUR) was achieved by mixing curcumin with copper acetate monohydrate. The solid residue was isolated, filtered, and dried in an oven. X-ray diffraction analysis was used to identify the structure and phase of the prepared samples. FTIR spectra were recorded using a Shimadzu 2200 module. The antimicrobial activity of the prepared complexes was evaluated against four bacterial strains and two Candida species. The chemical materials were dissolved in DMSO to a final concentration of 20%, and the plates were incubated at 37°C for 24 hours. The results showed that the prepared complexes had antimicrobial activity against the tested microorganisms.

Results: The study compared the Powder X-ray diffraction (XRD) patterns of prepared copper and cobalt complexes to pure curcumin, revealing new, isostructural complexes. The FTIR analysis showed that the Cu-CUR and Co-CUR complexes varied in their inhibitory effect against microorganisms, with Co-CUR being more effective. The results are consistent with previous studies showing the cobalt-curcumin complex was effective against various bacterial genera, with inhibition activity varying depending on the species and strains of microorganisms.

Conclusion: Copper and cobalt curcumin complexes, synthesized at room temperature, exhibit high crystallinity and antimicrobial activity. Co-CUR, with its superior antibacterial potential, outperforms pure curcumin in inhibiting microbes. Further investigation is needed to understand their interaction mechanisms with bacteria and fungi.

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来源期刊
CiteScore
5.80
自引率
0.00%
发文量
86
审稿时长
1 months
期刊介绍: Cellular Physiology and Biochemistry is a multidisciplinary scientific forum dedicated to advancing the frontiers of basic cellular research. It addresses scientists from both the physiological and biochemical disciplines as well as related fields such as genetics, molecular biology, pathophysiology, pathobiochemistry and cellular toxicology & pharmacology. Original papers and reviews on the mechanisms of intracellular transmission, cellular metabolism, cell growth, differentiation and death, ion channels and carriers, and the maintenance, regulation and disturbances of cell volume are presented. Appearing monthly under peer review, Cellular Physiology and Biochemistry takes an active role in the concerted international effort to unravel the mechanisms of cellular function.
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