加纳奥蒂地区的蛇咬伤和蛇毒使用情况:一项为期 6 年的回顾性研究。

IF 2.6 3区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
BioMed Research International Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI:10.1155/2024/6692421
Courage Edem Ketor, Charles Kwaku Benneh, Kofi Boamah Mensah, Emmanuel Sarkodie, Adelaide Mensah, Samuel Owusu Somuah, Selorm Akakpo, Kwame Ohene Buabeng
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引用次数: 0

摘要

背景:蛇咬伤是一种全球性的环境和职业危害,也是一种重大的公共卫生威胁。在农村地区,由于缺乏完善的医疗保健设施/基础设施,被蛇咬伤的病例往往得不到报告和记录。在某些情况下,抗蛇毒液(ASV)的需求量远远超过供应量,对治疗效果产生了负面影响。因此,本研究评估了被蛇咬伤病例的流行病学特征、其管理情况以及贾西干区医院所选医院如何使用抗蛇毒血清。研究方法利用抗蛇毒血清回执表(药房记录)、临床记录(患者文件夹)、地区健康信息管理系统-2(DHIMS-2)数据库和诊室登记簿中的二手数据,在加纳奥蒂省贾西坎地区的选定医院开展了一项为期 6 年的回顾性研究。研究结果被蛇咬伤的主要症状是局部疼痛(71.4%)。蛇咬伤通常发生在家中(19%)和农场(18%)。在 98 例蛇咬伤病例中,73 例(74.5%)接受了 ASV 治疗。辅助治疗包括预防性抗破伤风免疫球蛋白(ATS)(80.6%)、预防性抗生素(63%)、皮质类固醇(80.6%)和止痛药(63%)。据记录,95%(n = 94)的患者完全康复;三人不听医嘱出院,一人死亡。在高发病率的几个月里,抗蛇毒血清的供应和使用都不稳定,部分原因是地区医药商店的供应不稳定。抗蛇毒血清的平均瓶数和住院时间分别为 1.23 ± 0.86 瓶和 2.67 ± 1.97 天。虽然蛇咬伤的高峰期出现在四月、五月和六月,但四月和五月的抗蛇毒血清供不应求。结论尽管某些月份的抗蛇毒血清供应不足,但大多数蛇咬伤病例的处理结果是适当的。不稳定的抗蛇毒血清供应应与季节和设施使用模式保持一致,以加强区域蛇咬伤管理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Snakebites and Antisnake Venom Utilization in Ghana's Oti Region: A 6-Year Retrospective Study.

Background: Snakebite is a global environmental and occupational hazard and a significant public health threat. In rural areas, snakebite cases often go unreported and undocumented due to the lack of access to well-structured healthcare facilities/infrastructure. In some cases, the need for antisnake venom (ASV) far outstrips supply, negatively affecting treatment outcomes. This study, therefore, assessed the epidemiological characteristics of snakebite cases, their management, and how antivenoms are utilised at the selected hospital in the Jasikan District Hospital. Methods: A 6-year retrospective study using secondary data from antivenom return forms (pharmacy records), clinical records (patient folders), the District Health Information Management System-2 (DHIMS-2) database, and consulting room registers was carried out in selected hospitals in the Jasikan District, Oti, Ghana. Results: The predominant symptom of snakebite was localised pain (71.4%). The snakebite commonly occurred at home (19%) and on farms (18%). Of the 98 snakebite cases, ASV was administered to 73 (74.5%) cases. Supportive treatment applied included prophylactic antitetanus immunoglobulin (ATS) (80.6%), prophylactic antibiotics (63%), corticosteroids (80.6%), and analgesics (63%). 95% (n = 94) of complete recoveries were recorded; three were discharged against medical advice, and one was mortality. The supply and use of antivenom were erratic throughout the months of high incidence, partly due to inconsistent availability at the Regional Medical Stores. The average ASV vials and hospital stay duration were 1.23 ± 0.86 vials and 2.67 ± 1.97 days, respectively. Although the peak of snakebites occurs in April, May, and June, the demand for antivenom in April and May exceeded supply. Conclusion: The outcome of most snakebite case management was appropriate, irrespective of inadequate ASV supply in certain months. The erratic antivenom supply should be aligned with seasonal and facility-use patterns to enhance regional snakebite management.

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来源期刊
BioMed Research International
BioMed Research International BIOTECHNOLOGY & APPLIED MICROBIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
6.70
自引率
0.00%
发文量
1942
审稿时长
19 weeks
期刊介绍: BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
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