肯尼亚马铃薯(Solanum tuberosum)感染马铃薯病毒 Y 株系的分子足迹。

IF 1.1 Q4 VIROLOGY
Advances in Virology Pub Date : 2024-08-06 eCollection Date: 2024-01-01 DOI:10.1155/2024/2197725
Maryrose Nyakio, Mariam Were, Clabe Wekesa, Henry Lungayia, Patrick Okoth, Hassan Were
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引用次数: 0

摘要

马铃薯病毒 Y(PVY)是一种高度多样化、遗传易变的病毒,有多种毒株。据报道,马铃薯病毒属中的不同进化路线是由自然选择压力、变异和重组造成的,其毒力取决于不同的环境条件。尽管 PVY 对茄科植物具有重要的经济影响,但人们对其在肯尼亚的系统地理学的了解仍然有限,记录也不充分。这项研究的重点是对肯尼亚的一个 PVY 分离物(GenBank 编号 PP069009)进行分子鉴定。深入的系统进化分析揭示了肯尼亚分离株与来自美国的分离株[JQ924287]之间的密切进化联系,其支持概率高达 92%。重组分析揭示了肯尼亚分离物内部类似马赛克的遗传结构,表明存在多个基因重组事件。选择压力分析确定了受到选择压力的特定位点,有证据表明存在正选择/多样化选择和负选择/净化选择。群体遗传学分析表明,计算得出的核苷酸多样性(π)为 0.00354881,而分子方差分析(AMOVA)揭示了一个结构化的遗传景观,øST 值为 0.45224。广泛的单倍型网络表明,各大洲可能存在不同的 PVY 株系。这项分析为了解 PVY 的遗传多样性和全球分布提供了宝贵的信息,突出了了解进化动态对于在全球范围内有效管理和控制 PVY 的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular Footprints of Potato Virus Y Isolate Infecting Potatoes (Solanum tuberosum) in Kenya.

Potato virus Y (PVY) is a highly diverse and genetically variable virus with various strains. Differential evolutionary routes have been reported in the genus Potyvirus, caused by natural selection pressure, mutation, and recombination, with their virulence being dependent on different environmental conditions. Despite its significance and economic impact on Solanaceous species, the understanding of PVY's phylogeography in Kenya remains limited and inadequately documented. The study centers on the molecular characterization of a Kenyan PVY isolate, GenBank accession number PP069009. In-depth phylogenetic analysis unveiled a strong evolutionary association between the Kenyan isolate and isolate [JQ924287] from the United States of America, supported by a robust 92% probability. Recombinant analyses exposed a mosaic-like genetic architecture within the Kenyan isolate, indicating multiple gene recombination events. Selection pressure scrutiny identified specific sites under selective pressure, with evidence of positive/diversifying and negative/purifying selection. Population genetics analysis revealed a calculated nucleotide diversity (π) of 0.00354881, while analysis of molecular variance (AMOVA) unveiled a structured genetic landscape with an øST value of 0.45224. The extensive haplotype network depicted the possibility of diverse PVY strains occurring across continents. This analysis provides valuable insights into the genetic diversity and distribution of PVY globally, highlighting the importance of understanding evolutionary dynamics for effective management and control strategies of PVY on a global scale.

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来源期刊
CiteScore
2.30
自引率
0.00%
发文量
23
审稿时长
22 weeks
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