NHC 催化的自由基串联环化：α,α-二氟-γ-内酰胺衍生物的高效合成。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-28 DOI:10.1039/d4ob01012d

Tianjiao Huang , Huiping Yin , Tuanjie Li , Chenxia Yu , Kai Zhang , Changsheng Yao

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引用次数: 0

摘要

本文开发了一种 N-烯丙基溴二氟乙酰胺与醛的 N-杂环碳烯（NHC）催化自由基串联环化反应。该方法是合成α,α-二氟-γ-内酰胺衍生物的有效方法，收率从中等到良好（27 个实例，收率高达 88%，产率为 10 : 1 dr）。这种方法的特点是条件温和、不含金属、效率高、底物范围广。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

NHC catalyzed radical tandem cyclization: an efficient synthesis of α,α-difluoro-γ-lactam derivatives†

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NHC catalyzed radical tandem cyclization: an efficient synthesis of α,α-difluoro-γ-lactam derivatives†

Herein, an N-heterocyclic carbene (NHC) catalyzed radical tandem cyclization reaction of N-allylbromodifluoroacetamides and aldehydes has been developed. This method is an efficient protocol for synthesizing α,α-difluoro-γ-lactam derivatives in moderate to good yields (27 examples, up to 88% yield and 10 : 1 dr). This strategy features mild and metal-free conditions, high efficiency, and a broad substrate scope.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464