用于检测药物性肝损伤中过氧化氢的新型近红外-II 荧光探针

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2024-08-29 DOI:10.1039/d4cc03512g

Huiyu Chen , Hui Zhou , Xinyue Zhang , Yancheng Ding , Xiaolong Zhang , Qinqin Xu , Ben Wang , Chao Yin , Quli Fan

引用次数: 0

摘要

在第二个近红外（NIR-II）窗口合成可激活 H2O2 的小分子仍然具有挑战性。我们推出了用于实时检测 H2O2 的 NIR-II 探针 Z-1065。Z-1065 在体外显示出对 H2O2 的高灵敏度和选择性，并能在药物诱导肝损伤（DILI）小鼠模型中有效监测 H2O2 的生成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A novel NIR-II fluorescent probe for hydrogen peroxide detection in drug-induced liver injury†

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A novel NIR-II fluorescent probe for hydrogen peroxide detection in drug-induced liver injury†

The synthesis of H₂O₂-activatable small molecules in the second near-infrared (NIR-II) window remains challenging. We present the NIR-II probe Z-1065 for real-time detection of H₂O₂. Z-1065 demonstrates high sensitivity and selectivity towards H₂O₂in vitro and effectively monitors H₂O₂ generation in drug-induced liver injury (DILI) mouse models.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.