通过紫外可见光谱定量和定性分析芬太尼片剂中的染料--一种法医学方法。

IF 1.5 4区 医学 Q2 MEDICINE, LEGAL
Charley K. Mitchell BS, Jonathan C. Dumke PhD, Charlotte A. Corbett PhD, Laura M. Jones BS, Kristin E. Ceniccola-Campos PhD
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引用次数: 0

摘要

在美国,非法芬太尼通常以模仿 Mallinckrodt 公司生产的合法 M-30 羟考酮片剂的蓝色片剂形式贩运。对从缉获的芬太尼药片中提取的染料进行分析,可为执法部门提供有用的工具,以建立案件之间的联系,并可证明有助于将缉获归咎于特定的贩运组织。与特定贩毒组织(DTO)有关的芬太尼药片缉获量(通过调查或情报信息)被用作本研究的样本集。通过固相萃取从药片中分离出蓝色染料,然后通过紫外可见光谱进行定性和定量分析。这项研究发现,非法制片厂使用的染料与几家已知制药公司使用的染料不同。事实证明,缉获的单个药片中的染料浓度非常低,而且样本量较小,因此很难将不同案件联系起来。由于每个贩毒组织都使用同一种染料,因此对染料的分析无法有效区分被检测人群中的贩毒组织;但必须指出的是,在非法药片中发现的染料是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The quantitative and qualitative analysis of dye in fentanyl tablets via ultraviolet-visible spectroscopy—A forensic approach

In the United States, illicit fentanyl is often trafficked as blue tablets mimicking the legitimate M-30 oxycodone tablet produced by Mallinckrodt. The analysis of dyes extracted from seized fentanyl tablets could provide a useful tool for law enforcement to establish linkages between cases and could prove useful for attributing a seizure to a given trafficking organization. Fentanyl tablet seizures associated with a particular drug trafficking organization (DTO), either through investigative or intelligence information, were used as the sample set for this study. The blue dye from the tablets was isolated by solid phase extraction and then qualitatively and quantitatively analyzed via ultraviolet-visible spectroscopy. This research revealed that the illicit tableting facilities use a different dye than several known pharmaceutical companies. The concentration of dye in individual tablets within a seizure proved to be very minimal, and the small sample size made it difficult to draw linkages from case to case. Analysis of the dyes could not effectively differentiate between the drug trafficking organizations in the tested population due to each DTO using the same dye; however, it is important to note that the dye found was consistent between illicit tablets.

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来源期刊
Journal of forensic sciences
Journal of forensic sciences 医学-医学:法
CiteScore
4.00
自引率
12.50%
发文量
215
审稿时长
2 months
期刊介绍: The Journal of Forensic Sciences (JFS) is the official publication of the American Academy of Forensic Sciences (AAFS). It is devoted to the publication of original investigations, observations, scholarly inquiries and reviews in various branches of the forensic sciences. These include anthropology, criminalistics, digital and multimedia sciences, engineering and applied sciences, pathology/biology, psychiatry and behavioral science, jurisprudence, odontology, questioned documents, and toxicology. Similar submissions dealing with forensic aspects of other sciences and the social sciences are also accepted, as are submissions dealing with scientifically sound emerging science disciplines. The content and/or views expressed in the JFS are not necessarily those of the AAFS, the JFS Editorial Board, the organizations with which authors are affiliated, or the publisher of JFS. All manuscript submissions are double-blind peer-reviewed.
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