抗肿瘤药物的心肌毒性机制及潜在治疗策略：文献综述。

IF 3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2024-08-10 DOI:10.1016/j.cpcardiol.2024.102782

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引用次数: 0

摘要

随着化疗药物的不断发展，临床应用取得了良好的效果。然而，心肌毒性是最大的挑战。蒽环类、免疫检查点抑制剂和铂类药物被广泛应用。靶向给药、纳米材料和动态成像评估都是新兴的研究方向。本文综述了利用纳米药物靶向给药和成像技术评估抗肿瘤药物心肌毒性的最新文献，并探讨了其潜在机制。

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Mechanisms of myocardial toxicity of antitumor drugs and potential therapeutic strategies: A review of the literature

With the successive development of chemotherapy drugs, good results have been achieved in clinical application. However, myocardial toxicity is the biggest challenge. Anthracyclines, immune checkpoint inhibitors, and platinum drugs are widely used. Targeted drug delivery, nanomaterials and dynamic imaging evaluation are all emerging research directions. This article reviews the recent literature on the use of targeted nanodrug delivery and imaging techniques to evaluate the myocardial toxicity of antineoplastic drugs, and discusses the potential mechanisms.

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.