{"title":"在一组系统性红斑狼疮患者中识别肺部并发症的回顾性队列研究。","authors":"Jessica S Johnson, Chao Zhang, Emily Littlejohn","doi":"10.1177/09612033241273071","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi organ involvement. One of the most common manifestations is pulmonary disease with a reported prevalence between 5%-90%.</p><p><strong>Purpose: </strong>Given this wide range of prevalence, there is a need to more closely define types of pulmonary disease in SLE and associated risk factors.</p><p><strong>Research design: </strong>We sought to characterize the presentation of pulmonary manifestations in an established SLE cohort using electronic health record data.</p><p><strong>Study sample: </strong>All patients were >18 years of age and had confirmed SLE by a rheumatologist using SLICC or 2019 ACR/EULAR classification criteria. 220 patients with imaging were included in this study; average age was 42.5 years, 86.7% identified as female, 60.5% identified as white, 37.3% as Black, and 1.82% as Asian.</p><p><strong>Analysis: </strong>Generalized estimating equations were utilized to analyze the data, accounting for its repeated measured nature.</p><p><strong>Results: </strong>We found an association between smoking (present/prior smoker) and radiologist reported disease on computerized tomography (CT) scan, as well as an association between smoking (present/prior smoker), older age, and male sex with having pulmonary disease identified on chest X-ray. The most common findings on CT and X-ray were increased lung density (24%, 12%) and atelectasis (18%, 10%). The most common disease found on CT was pleural effusion (24%) and mediastinal/axillary lymphadenopathy (16%).</p><p><strong>Conclusion: </strong>While our study is limited by the retrospective nature, our results show that certain factors, namely smoking, older age, or male sex should prompt clinicians to have a higher suspicion for lung disease in SLE patients.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1242-1247"},"PeriodicalIF":1.9000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Retrospective cohort study identifying pulmonary complications in a cohort of patients with systemic lupus erythematosus.\",\"authors\":\"Jessica S Johnson, Chao Zhang, Emily Littlejohn\",\"doi\":\"10.1177/09612033241273071\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi organ involvement. One of the most common manifestations is pulmonary disease with a reported prevalence between 5%-90%.</p><p><strong>Purpose: </strong>Given this wide range of prevalence, there is a need to more closely define types of pulmonary disease in SLE and associated risk factors.</p><p><strong>Research design: </strong>We sought to characterize the presentation of pulmonary manifestations in an established SLE cohort using electronic health record data.</p><p><strong>Study sample: </strong>All patients were >18 years of age and had confirmed SLE by a rheumatologist using SLICC or 2019 ACR/EULAR classification criteria. 220 patients with imaging were included in this study; average age was 42.5 years, 86.7% identified as female, 60.5% identified as white, 37.3% as Black, and 1.82% as Asian.</p><p><strong>Analysis: </strong>Generalized estimating equations were utilized to analyze the data, accounting for its repeated measured nature.</p><p><strong>Results: </strong>We found an association between smoking (present/prior smoker) and radiologist reported disease on computerized tomography (CT) scan, as well as an association between smoking (present/prior smoker), older age, and male sex with having pulmonary disease identified on chest X-ray. The most common findings on CT and X-ray were increased lung density (24%, 12%) and atelectasis (18%, 10%). The most common disease found on CT was pleural effusion (24%) and mediastinal/axillary lymphadenopathy (16%).</p><p><strong>Conclusion: </strong>While our study is limited by the retrospective nature, our results show that certain factors, namely smoking, older age, or male sex should prompt clinicians to have a higher suspicion for lung disease in SLE patients.</p>\",\"PeriodicalId\":18044,\"journal\":{\"name\":\"Lupus\",\"volume\":\" \",\"pages\":\"1242-1247\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lupus\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/09612033241273071\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033241273071","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景:系统性红斑狼疮(SLE)是一种全身性自身免疫性疾病,可累及多个器官。目的:鉴于这种广泛的发病率,有必要更仔细地界定系统性红斑狼疮肺部疾病的类型以及相关的风险因素:研究样本:研究样本:所有患者的年龄均大于18岁,并由风湿免疫科医生根据SLICC或2019 ACR/EULAR分类标准确诊为系统性红斑狼疮。本研究共纳入 220 名有影像学检查的患者;平均年龄为 42.5 岁,86.7% 为女性,60.5% 为白人,37.3% 为黑人,1.82% 为亚裔:分析:考虑到数据的重复测量性质,我们采用了广义估计方程对数据进行分析:结果:我们发现吸烟(现在/以前吸烟)与放射科医生报告的计算机断层扫描(CT)疾病之间存在关联,吸烟(现在/以前吸烟)、年龄较大和男性与胸部 X 光检查发现肺部疾病之间也存在关联。CT 和 X 光片上最常见的发现是肺密度增高(24%,12%)和肺不张(18%,10%)。CT 上最常见的疾病是胸腔积液(24%)和纵隔/腋窝淋巴结病(16%):虽然我们的研究是回顾性的,但结果表明,某些因素,即吸烟、年龄较大或男性,应促使临床医生对系统性红斑狼疮患者的肺部疾病有更高的怀疑。
Retrospective cohort study identifying pulmonary complications in a cohort of patients with systemic lupus erythematosus.
Background: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with multi organ involvement. One of the most common manifestations is pulmonary disease with a reported prevalence between 5%-90%.
Purpose: Given this wide range of prevalence, there is a need to more closely define types of pulmonary disease in SLE and associated risk factors.
Research design: We sought to characterize the presentation of pulmonary manifestations in an established SLE cohort using electronic health record data.
Study sample: All patients were >18 years of age and had confirmed SLE by a rheumatologist using SLICC or 2019 ACR/EULAR classification criteria. 220 patients with imaging were included in this study; average age was 42.5 years, 86.7% identified as female, 60.5% identified as white, 37.3% as Black, and 1.82% as Asian.
Analysis: Generalized estimating equations were utilized to analyze the data, accounting for its repeated measured nature.
Results: We found an association between smoking (present/prior smoker) and radiologist reported disease on computerized tomography (CT) scan, as well as an association between smoking (present/prior smoker), older age, and male sex with having pulmonary disease identified on chest X-ray. The most common findings on CT and X-ray were increased lung density (24%, 12%) and atelectasis (18%, 10%). The most common disease found on CT was pleural effusion (24%) and mediastinal/axillary lymphadenopathy (16%).
Conclusion: While our study is limited by the retrospective nature, our results show that certain factors, namely smoking, older age, or male sex should prompt clinicians to have a higher suspicion for lung disease in SLE patients.
期刊介绍:
The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…