肺移植受者体内 SARS-CoV-2 体液免疫和细胞免疫的持续缺陷。

IF 6.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Heart and Lung Transplantation Pub Date : 2024-08-10 DOI:10.1016/j.healun.2024.08.002

Isabelle Etienne MD , Delphine Kemlin MD , Nicolas Gemander MD , Véronique Olislagers MSc , Alexandra Waegemans , Emilie Dhondt MSc , Leo Heyndrickx MSc , Stéphanie Depickère MSc, PhD , Alexia Charles MSc, PhD , Maria Goossens MD, PhD , Leen Vandermosten MSc, PhD , Isabelle Desombere MSc, PhD , Kevin K. Ariën MSc, PhD , Pieter Pannus PhD , Christiane Knoop MD, PhD , Arnaud Marchant MD, PhD

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引用次数: 0

摘要

肺移植受者（LTR）容易感染严重的 COVID-19，与普通人群和其他实体器官移植受者相比，他们对 SARS-CoV-2 疫苗初次接种的免疫反应较低。自大流行开始以来，普通人群通过加强免疫接种和自然感染获得的免疫力有所提高，但 LTR 获得的免疫力却没有得到很好的记录。2023 年 2 月和 5 月，对 30 名 LTR 的 SARS-CoV-2 体液免疫和细胞免疫进行了监测，并与医护人员（HCW）和疗养院居民（NHR）进行了比较。与医护人员和养老院居民相比，LTR 的 SARS-CoV-2 结合抗体和中和抗体水平明显较低，对武汉、Delta 和 XBB1.5 变种的 IFN-γ 反应也较低。两次访视之间，体液免疫力下降，而细胞免疫力保持稳定。LTR 中 SARS-CoV-2 免疫力的持续缺陷应鼓励对这一易感人群进行持续监测并采取预防措施。

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Persistent defect in SARS-CoV-2 humoral and cellular immunity in lung transplant recipients

Lung transplant recipients (LTRs) are susceptible to severe Coronavirus Disease 2019 (COVID-19) and had lower immune responses to primary severe acute respiratory syndrome-related to coronavirus 2 (SARS-CoV-2) vaccination as compared to the general population and to other solid organ transplant recipients. As immunity induced by booster vaccination and natural infection has increased since the beginning of the pandemic in the general population, immunity acquired by LTRs is not well documented. Humoral and cellular immunity to SARS-CoV-2 was monitored in February and May 2023 in 30 LTRs and compared to that of health care workers (HCWs) and nursing home residents (NHRs). LTRs had significantly lower levels of SARS-CoV-2 binding and neutralizing antibodies and lower interferon-gamma responses to Wuhan, Delta, and XBB1.5 variants as compared to HCWs and NHRs. Humoral immunity decreased between the 2 visits, whereas cellular immunity remained more stable. The persistent defect in SARS-CoV-2 immunity in LTRs should encourage continued monitoring and preventive measures for this vulnerable population.

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来源期刊

Journal of Heart and Lung Transplantation 医学-呼吸系统

CiteScore

10.10

自引率

6.70%

发文量

1667

审稿时长

69 days

期刊介绍： The Journal of Heart and Lung Transplantation, the official publication of the International Society for Heart and Lung Transplantation, brings readers essential scholarly and timely information in the field of cardio-pulmonary transplantation, mechanical and biological support of the failing heart, advanced lung disease (including pulmonary vascular disease) and cell replacement therapy. Importantly, the journal also serves as a medium of communication of pre-clinical sciences in all these rapidly expanding areas.