Byung-Keun Kim, Hwan-Cheol Kim, Dong-Wook Lee, Young-Hee Nam, Da Woon Sim, Youngsoo Lee, Ji-Su Shim, Min-Suk Yang, Min-Hye Kim, So Ri Kim, Sang-Heon Kim, Young-Il Koh, Heung-Woo Park
{"title":"住宅区的室内环境和室外空气污染物对严重哮喘患者病情急性加重的影响。","authors":"Byung-Keun Kim, Hwan-Cheol Kim, Dong-Wook Lee, Young-Hee Nam, Da Woon Sim, Youngsoo Lee, Ji-Su Shim, Min-Suk Yang, Min-Hye Kim, So Ri Kim, Sang-Heon Kim, Young-Il Koh, Heung-Woo Park","doi":"10.1080/09603123.2024.2390474","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to determine the effects of indoor environment (IE) and outdoor air pollutants (OAPs) in residential areas on acute exacerbation (AE) in patients with severe asthma. A total of 115 participants were recruited. To characterize IE, we used structured questionnaires and estimated OAP concentrations using a land-use regression model. Participants who were exposed to passive smoking and lived in houses where the kitchen and living room were not separated showed a significantly higher rate of AE (<i>p</i> = 0.014 and 0.0016, respectively). The mean concentration of PM<sub>2.5</sub> in residential areas during the last 3 years was significantly higher in participants with AE than that in those without AE (19.8 ± 3.1 <i>vs</i>. 21.0 ± 2.5 µg/m<sup>3</sup>, <i>p</i> = 0.033). Moreover, the serum level of 8-hydroxy-2'-deoxyguanosine significantly increased in participants with AE compared to those without AE (56.9 ± 30.0 <i>vs</i>. 94.7 ± 44.5 ng/mL, <i>p</i> = 0.0047) suggesting enhanced oxidative stress in those with AE.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of indoor environments and outdoor air pollutants in residential areas on acute exacerbation in patients with severe asthma.\",\"authors\":\"Byung-Keun Kim, Hwan-Cheol Kim, Dong-Wook Lee, Young-Hee Nam, Da Woon Sim, Youngsoo Lee, Ji-Su Shim, Min-Suk Yang, Min-Hye Kim, So Ri Kim, Sang-Heon Kim, Young-Il Koh, Heung-Woo Park\",\"doi\":\"10.1080/09603123.2024.2390474\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aimed to determine the effects of indoor environment (IE) and outdoor air pollutants (OAPs) in residential areas on acute exacerbation (AE) in patients with severe asthma. A total of 115 participants were recruited. To characterize IE, we used structured questionnaires and estimated OAP concentrations using a land-use regression model. Participants who were exposed to passive smoking and lived in houses where the kitchen and living room were not separated showed a significantly higher rate of AE (<i>p</i> = 0.014 and 0.0016, respectively). The mean concentration of PM<sub>2.5</sub> in residential areas during the last 3 years was significantly higher in participants with AE than that in those without AE (19.8 ± 3.1 <i>vs</i>. 21.0 ± 2.5 µg/m<sup>3</sup>, <i>p</i> = 0.033). Moreover, the serum level of 8-hydroxy-2'-deoxyguanosine significantly increased in participants with AE compared to those without AE (56.9 ± 30.0 <i>vs</i>. 94.7 ± 44.5 ng/mL, <i>p</i> = 0.0047) suggesting enhanced oxidative stress in those with AE.</p>\",\"PeriodicalId\":14039,\"journal\":{\"name\":\"International Journal of Environmental Health Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-08-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Environmental Health Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/09603123.2024.2390474\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Environmental Health Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/09603123.2024.2390474","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Effects of indoor environments and outdoor air pollutants in residential areas on acute exacerbation in patients with severe asthma.
This study aimed to determine the effects of indoor environment (IE) and outdoor air pollutants (OAPs) in residential areas on acute exacerbation (AE) in patients with severe asthma. A total of 115 participants were recruited. To characterize IE, we used structured questionnaires and estimated OAP concentrations using a land-use regression model. Participants who were exposed to passive smoking and lived in houses where the kitchen and living room were not separated showed a significantly higher rate of AE (p = 0.014 and 0.0016, respectively). The mean concentration of PM2.5 in residential areas during the last 3 years was significantly higher in participants with AE than that in those without AE (19.8 ± 3.1 vs. 21.0 ± 2.5 µg/m3, p = 0.033). Moreover, the serum level of 8-hydroxy-2'-deoxyguanosine significantly increased in participants with AE compared to those without AE (56.9 ± 30.0 vs. 94.7 ± 44.5 ng/mL, p = 0.0047) suggesting enhanced oxidative stress in those with AE.
期刊介绍:
International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.