Taha Monadi, Zahra Mohajer, Afsaneh Soltani, Mohammad Amin Khazeei Tabari, Azadeh Manayi, Mohammad Azadbakht
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引用次数: 0
摘要
芹菜素是一种膳食类黄酮,因其在辐射防护和放射增敏方面的潜在治疗应用而受到越来越多的关注。电离辐射(IR)会伤害健康细胞,但放射治疗在癌症治疗中仍然至关重要。由于放疗在癌症治疗中的显著应用,在提高癌细胞对辐射敏感性的同时保护健康细胞免受辐射危害至关重要。本文回顾了目前对芹菜素的辐射防护和辐射敏感特性的认识,重点介绍了其中涉及的信号通路和关键分子靶点。当受到辐照时,芹菜素会通过抑制环氧化酶-2来减轻炎症,并调节促凋亡和抗凋亡生物标志物。芹菜素的自由基清除能力和抗氧化能力可减轻 DNA 的氧化损伤。它能抑制辐射诱导的哺乳动物雷帕霉素靶点激活、血管内皮生长因子(VEGF)、基质金属蛋白酶-2(MMP)和 STAT3 的表达,同时促进 AMPK、自噬和细胞凋亡,这表明芹菜素具有预防癌症的潜力。作为一种放射增敏剂,芹菜素通过诱导细胞凋亡、抑制血管内皮生长因子-C、肿瘤坏死因子α和 STAT3、降低 MMP-2/9 活性以及抑制癌细胞葡萄糖摄取来抑制肿瘤生长。细胞和动物研究支持芹菜素的放射保护和抗癌潜力,使其成为进一步研究的潜在候选物质。研究芹菜素对不同癌症类型和辐射损伤的疗效至关重要。
The influence of apigenin on cellular responses to radiation: From protection to sensitization.
Apigenin, a dietary flavonoid, has gained increasing attention for its potential therapeutic applications in radiation protection and radiosensitization. Ionizing radiation (IR) can harm healthy cells, but as radiotherapy remains crucial in cancer treatment. Owing to the remarkable application of radiotherapy in the treatment of cancers, it is vital to protect healthy cells from radiation hazards while increasing the sensitivity of cancer cells to radiation. This article reviews the current understanding of apigenin's radioprotective and radiosensitive properties with a focuses on the involved signaling pathways and key molecular targets. When exposed to irradiation, apigenin reduces inflammation via cyclooxygenase-2 inhibition and modulates proapoptotic and antiapoptotic biomarkers. Apigenin's radical scavenging abilities and antioxidant enhancement mitigate oxidative DNA damage. It inhibits radiation-induced mammalian target of rapamycin activation, vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP), and STAT3 expression, while promoting AMPK, autophagy, and apoptosis, suggesting potential in cancer prevention. As a radiosensitizer, apigenin inhibits tumor growth by inducing apoptosis, suppressing VEGF-C, tumor necrosis factor alpha, and STAT3, reducing MMP-2/9 activity, and inhibiting cancer cell glucose uptake. Cellular and animal studies support apigenin's radioprotective and anticancer potential, making it a potential candidate for further research. Investigation into apigenin's therapeutic efficacy in diverse cancer types and radiation damage is essential.
期刊介绍:
BioFactors, a journal of the International Union of Biochemistry and Molecular Biology, is devoted to the rapid publication of highly significant original research articles and reviews in experimental biology in health and disease.
The word “biofactors” refers to the many compounds that regulate biological functions. Biological factors comprise many molecules produced or modified by living organisms, and present in many essential systems like the blood, the nervous or immunological systems. A non-exhaustive list of biological factors includes neurotransmitters, cytokines, chemokines, hormones, coagulation factors, transcription factors, signaling molecules, receptor ligands and many more. In the group of biofactors we can accommodate several classical molecules not synthetized in the body such as vitamins, micronutrients or essential trace elements.
In keeping with this unified view of biochemistry, BioFactors publishes research dealing with the identification of new substances and the elucidation of their functions at the biophysical, biochemical, cellular and human level as well as studies revealing novel functions of already known biofactors. The journal encourages the submission of studies that use biochemistry, biophysics, cell and molecular biology and/or cell signaling approaches.