Haohao Jiang , Kaidi Jin , Xia Lin , Mengzhao Yu , Xiaohui Xiao , Xiaolei Huang
{"title":"在 NaBr/NaBrO3/H2SO4 作为溴化试剂的情况下，选择性地对苯乙烷进行 1,1- 和 1,2- 二溴反应。","authors":"Haohao Jiang , Kaidi Jin , Xia Lin , Mengzhao Yu , Xiaohui Xiao , Xiaolei Huang","doi":"10.1039/d4ob01016g","DOIUrl":null,"url":null,"abstract":"<div><p>Selective 1,1- and 1,2-dibromination of phenylethanes by simply adjusting the reaction conditions has been developed. Mixtures of NaBr/NaBrO<sub>3</sub>/H<sub>2</sub>SO<sub>4</sub> are employed as green bromination reagents, which can release Br<sub>2</sub> or BrOH <em>in situ</em> as required without polluting the environment. Both the resulting 1,1- and 1,2-dibromoethyl arenes can be easily transformed to phenylacetylenes <em>via</em> elimination under basic conditions, demonstrating great potential for industrial applications.</p></div>","PeriodicalId":2,"journal":{"name":"ACS Applied Bio Materials","volume":null,"pages":null},"PeriodicalIF":4.6000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Selective 1,1- and 1,2-dibromination of phenylethanes in the presence of NaBr/NaBrO3/H2SO4 as the bromination reagent†\",\"authors\":\"Haohao Jiang , Kaidi Jin , Xia Lin , Mengzhao Yu , Xiaohui Xiao , Xiaolei Huang\",\"doi\":\"10.1039/d4ob01016g\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Selective 1,1- and 1,2-dibromination of phenylethanes by simply adjusting the reaction conditions has been developed. Mixtures of NaBr/NaBrO<sub>3</sub>/H<sub>2</sub>SO<sub>4</sub> are employed as green bromination reagents, which can release Br<sub>2</sub> or BrOH <em>in situ</em> as required without polluting the environment. Both the resulting 1,1- and 1,2-dibromoethyl arenes can be easily transformed to phenylacetylenes <em>via</em> elimination under basic conditions, demonstrating great potential for industrial applications.</p></div>\",\"PeriodicalId\":2,\"journal\":{\"name\":\"ACS Applied Bio Materials\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.6000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Bio Materials\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S147705202400702X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Bio Materials","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S147705202400702X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Selective 1,1- and 1,2-dibromination of phenylethanes in the presence of NaBr/NaBrO3/H2SO4 as the bromination reagent†
Selective 1,1- and 1,2-dibromination of phenylethanes by simply adjusting the reaction conditions has been developed. Mixtures of NaBr/NaBrO3/H2SO4 are employed as green bromination reagents, which can release Br2 or BrOH in situ as required without polluting the environment. Both the resulting 1,1- and 1,2-dibromoethyl arenes can be easily transformed to phenylacetylenes via elimination under basic conditions, demonstrating great potential for industrial applications.
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