与衰老相关的心房颤动:以潜在机制为重点的全面综述。

IF 7.8 1区 医学 Q1 Biochemistry, Genetics and Molecular Biology
Aging Cell Pub Date : 2024-08-12 DOI:10.1111/acel.14309
Meng-Fei Wang, Can Hou, Fang Jia, Cheng-Hao Zhong, Cong Xue, Jian-Jun Li
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引用次数: 0

摘要

心房颤动(房颤)是一种极为常见的临床症状,因此一直受到科学家和临床医生的广泛关注。由于其特殊的血流动力学变化,房颤的致残率和死亡率都很高。迄今为止,虽然房颤已有一定的治疗手段,但由于其复杂的危险因素和病理生理机制,仍是一种无法治愈的疾病,是全球公共卫生领域的难题。年龄是心房颤动的重要独立危险因素,心房颤动的发病率随年龄增长而增加。迄今为止,还没有关于衰老相关房颤的全面综述。在这篇综述中,我们系统地讨论了衰老相关性心房颤动的病理生理学证据,特别是探讨了近期衰老相关性心房颤动研究中涉及的线粒体功能障碍、端粒损耗、细胞衰老、大自噬功能障碍和肠道菌群失调等病理生理学机制。我们希望通过探索衰老相关性房颤的各个层面,更好地理解年龄与房颤之间的特定关系,这对于创新性治疗衰老相关性房颤可能至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Aging-associated atrial fibrillation: A comprehensive review focusing on the potential mechanisms

Aging-associated atrial fibrillation: A comprehensive review focusing on the potential mechanisms

Aging-associated atrial fibrillation: A comprehensive review focusing on the potential mechanisms

Atrial fibrillation (AF) has been receiving a lot of attention from scientists and clinicians because it is an extremely common clinical condition. Due to its special hemodynamic changes, AF has a high rate of disability and mortality. So far, although AF has some therapeutic means, it is still an incurable disease because of its complex risk factors and pathophysiologic mechanisms, which is a difficult problem for global public health. Age is an important independent risk factor for AF, and the incidence of AF increases with age. To date, there is no comprehensive review on aging-associated AF. In this review, we systematically discuss the pathophysiologic evidence for aging-associated AF, and in particular explore the pathophysiologic mechanisms of mitochondrial dysfunction, telomere attrition, cellular senescence, disabled macroautophagy, and gut dysbiosis involved in recent studies with aging-associated AF. We hope that by exploring the various dimensions of aging-associated AF, we can better understand the specific relationship between age and AF, which may be crucial for innovative treatments of aging-associated AF.

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来源期刊
Aging Cell
Aging Cell 生物-老年医学
CiteScore
14.40
自引率
2.60%
发文量
212
审稿时长
8 weeks
期刊介绍: Aging Cell, an Open Access journal, delves into fundamental aspects of aging biology. It comprehensively explores geroscience, emphasizing research on the mechanisms underlying the aging process and the connections between aging and age-related diseases.
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