尿急对膀胱过度活跃成人的影响和负担回顾

IF 2.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Adrian Wagg, A. Lenore Ackerman, H. Henry Lai, Diane K. Newman
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引用次数: 0

摘要

膀胱过度活动症(OAB)是一种影响男性和女性生活质量的常见疾病,对许多人来说,尿急是最令人烦恼的症状。尿急被认为是其他症状(尿频、夜尿、尿急尿失禁 [UUI])的诱因。然而,在临床试验中,尿急症状一直未得到充分研究,这可能是由于对其进行评估本身就存在困难。多年来,与 OAB 相关的尿急定义不断完善,但患者和临床医生可能不易理解,从而影响了其在实践中的应用。测量尿急程度的工具各不相同,使问题更加复杂。例如,有些工具测量尿急发作的频率,并将减少发作频率视为改善尿急严重程度。其他一些方法则根据量表对每次尿急发作的严重程度进行评分,其中一些方法将伴随的尿失禁发作作为最严重的形式。尿急发作次数的减少通常是临床研究的主要终点,许多研究都要求将尿急(有时称为 OAB-湿性)作为纳入标准,但约有三分之二的 OAB 患者不会出现尿急。如果纳入了没有 UUI 的 OAB 患者(即干性 OAB),通常也不会对他们进行单独分析。因此,有 UUI 和没有 UUI 的患者在治疗效果上是否存在差异,以及这些差异是否由病理生理过程驱动,目前仍是未知数。本叙述性综述重点介绍了有关急迫感病理生理学、急迫感如何影响 OAB 患者、急迫感测量和相关挑战以及临床试验中急迫感评估的已知知识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Review of the Impact and Burden of Urinary Urgency on Adults with Overactive Bladder

Overactive bladder (OAB) is a prevalent condition that impairs the quality of life in both men and women, and for many, urgency is the most bothersome symptom. Urgency is thought to drive the presentation of the other symptoms (frequency, nocturia, urgency urinary incontinence [UUI]). However, urgency has been understudied in clinical trials, potentially owing to inherent difficulties in its assessment. The definition of urgency related to OAB has been refined over the years, but it may not be easily understood by patients and clinicians, affecting its use in practice. Variability among the tools to measure urgency further complicates the matter. For example, some measure the frequency of urgency episodes and consider reduction of episode frequency as improvement in urgency severity. Others rate the severity of each episode of urgency along a scale, with some including an accompanying incontinence episode as the most severe form. Reduction in UUI episodes is often a primary endpoint in clinical studies, with many studies requiring UUI—sometimes called OAB-wet—as an inclusion criterion, yet approximately two-thirds of those with OAB do not experience UUI. If patients with OAB without UUI (i.e., OAB-dry) are included, they are often not analyzed separately. Thus, it remains unknown if there are differences in treatment outcomes between patients with and without UUI and whether these differences are driven by pathophysiological processes. This narrative review highlights what is known about the pathophysiology of urgency, how urgency affects individuals with OAB, urgency measurement and associated challenges, and assessment of urgency in clinical trials.

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来源期刊
CiteScore
5.30
自引率
0.00%
发文量
274
审稿时长
3-8 weeks
期刊介绍: IJCP is a general medical journal. IJCP gives special priority to work that has international appeal. IJCP publishes: Editorials. IJCP Editorials are commissioned. [Peer reviewed at the editor''s discretion] Perspectives. Most IJCP Perspectives are commissioned. Example. [Peer reviewed at the editor''s discretion] Study design and interpretation. Example. [Always peer reviewed] Original data from clinical investigations. In particular: Primary research papers from RCTs, observational studies, epidemiological studies; pre-specified sub-analyses; pooled analyses. [Always peer reviewed] Meta-analyses. [Always peer reviewed] Systematic reviews. From October 2009, special priority will be given to systematic reviews. [Always peer reviewed] Non-systematic/narrative reviews. From October 2009, reviews that are not systematic will be considered only if they include a discrete Methods section that must explicitly describe the authors'' approach. Special priority will, however, be given to systematic reviews. [Always peer reviewed] ''How to…'' papers. Example. [Always peer reviewed] Consensus statements. [Always peer reviewed] Short reports. [Always peer reviewed] Letters. [Peer reviewed at the editor''s discretion] International scope IJCP publishes work from investigators globally. Around 30% of IJCP articles list an author from the UK. Around 30% of IJCP articles list an author from the USA or Canada. Around 45% of IJCP articles list an author from a European country that is not the UK. Around 15% of articles published in IJCP list an author from a country in the Asia-Pacific region.
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