Xiangyang Zhang, Buyue Zhang, Ying Zhang, Yinghao Ding, Zhenghao Zhang, Prof. Qian Liu, Prof. Zhimou Yang, Prof. Ling Wang, Prof. Jie Gao
{"title":"Rücktitelbild:铜诱导超分子肽组装,用于多途径细胞死亡和肿瘤抑制(Angew.)","authors":"Xiangyang Zhang, Buyue Zhang, Ying Zhang, Yinghao Ding, Zhenghao Zhang, Prof. Qian Liu, Prof. Zhimou Yang, Prof. Ling Wang, Prof. Jie Gao","doi":"10.1002/ange.202413964","DOIUrl":null,"url":null,"abstract":"<p><b>The immunosuppressive tumor microenvironment</b> leads to insufficient infiltration of effector lymphocytes, significantly weakening the anti-tumor immune response and promoting the tumor to become “cold”. In the cover image, tumor cells are representend as icebergs, with organelles as ice blocks floating on the ice surface. The copper peptide nanoparticles are meteorites falling from the sky, attacking multiple organelles. The ice begins to melt, symbolizing the elicited multiple cell death pathways, and also indicating the transformation of cold tumors into hot tumors, as illustrated by Ling Wang, Jie Gao et al. in their Research Article (e202406602).\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure>\n </p>","PeriodicalId":7803,"journal":{"name":"Angewandte Chemie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202413964","citationCount":"0","resultStr":"{\"title\":\"Rücktitelbild: Copper-Induced Supramolecular Peptide Assemblies for Multi-Pathway Cell Death and Tumor Inhibition (Angew. Chem. 34/2024)\",\"authors\":\"Xiangyang Zhang, Buyue Zhang, Ying Zhang, Yinghao Ding, Zhenghao Zhang, Prof. Qian Liu, Prof. Zhimou Yang, Prof. Ling Wang, Prof. Jie Gao\",\"doi\":\"10.1002/ange.202413964\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>The immunosuppressive tumor microenvironment</b> leads to insufficient infiltration of effector lymphocytes, significantly weakening the anti-tumor immune response and promoting the tumor to become “cold”. In the cover image, tumor cells are representend as icebergs, with organelles as ice blocks floating on the ice surface. The copper peptide nanoparticles are meteorites falling from the sky, attacking multiple organelles. The ice begins to melt, symbolizing the elicited multiple cell death pathways, and also indicating the transformation of cold tumors into hot tumors, as illustrated by Ling Wang, Jie Gao et al. in their Research Article (e202406602).\\n <figure>\\n <div><picture>\\n <source></source></picture><p></p>\\n </div>\\n </figure>\\n </p>\",\"PeriodicalId\":7803,\"journal\":{\"name\":\"Angewandte Chemie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ange.202413964\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Angewandte Chemie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/ange.202413964\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Angewandte Chemie","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/ange.202413964","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Rücktitelbild: Copper-Induced Supramolecular Peptide Assemblies for Multi-Pathway Cell Death and Tumor Inhibition (Angew. Chem. 34/2024)
The immunosuppressive tumor microenvironment leads to insufficient infiltration of effector lymphocytes, significantly weakening the anti-tumor immune response and promoting the tumor to become “cold”. In the cover image, tumor cells are representend as icebergs, with organelles as ice blocks floating on the ice surface. The copper peptide nanoparticles are meteorites falling from the sky, attacking multiple organelles. The ice begins to melt, symbolizing the elicited multiple cell death pathways, and also indicating the transformation of cold tumors into hot tumors, as illustrated by Ling Wang, Jie Gao et al. in their Research Article (e202406602).