从天竺葵茎中提取的两种新的新clerodane二萜类化合物

IF 1.3 4区生物学 Q4 CHEMISTRY, MEDICINAL

Phytochemistry Letters Pub Date : 2024-08-10 DOI:10.1016/j.phytol.2024.08.004

Nhat Nam Hoang , Shotaro Hoshino , Takeshi Kodama , Thao Xuan Hoang , Hiroyasu Onaka , Hiroyuki Morita

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引用次数: 0

摘要

通过对 Tinospora cordifolia 茎的 70% 乙醇提取物进行植物化学研究，分离出了两种新的新萜类二萜，包括 tinocordifoliols C (1) 和 D (2)。通过实验一维和二维核磁共振、HR-ESI-MS、ECD 和统计分析（包括基于核磁共振化学位移的 DFT 计算得出的 DP4+ 概率），确定了它们的结构。根据之前关于两种新环戊烷二萜锡芴醇 A 和 B 的报告，还评估了 1 和 2 对人类精氨酸酶 I 和 II 的抑制活性。与之前报道的两种新橙皮烷二萜相比，1 和 2 没有显示出对人类精氨酸酶 I 和 II 的抑制活性。这些结果有助于深入了解新橙皮二萜的结构-活性关系。

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Two new neo-clerodane diterpenoids from Tinospora cordifolia stems

Phytochemical studies of the 70 % ethanol extract of Tinospora cordifolia stems led to the isolation of two new neo-clerodane diterpenoids, including tinocordifoliols C (1) and D (2). Their structures were determined by experimental 1D and 2D NMR, HR-ESI-MS, ECD, and statistical analyses, including DP4+ probability based on DFT calculations of NMR chemical shifts. According to the previous report for two neo-clerodane diterpenoids, tinocordifoliols A and B, the inhibitory activities of 1 and 2 against human arginases I and II were also evaluated. In contrast to the previously reported two neo-clerodane diterpenoids, 1 and 2 did not show inhibitory activities against human arginases I and II. These results provide insight into the structure-activity relationship of neo-clerodane diterpenoids.

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来源期刊

Phytochemistry Letters 生物-生化与分子生物学

CiteScore

3.00

自引率

11.80%

发文量

190

审稿时长

34 days

期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.