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东方马兜铃中的两种新的孕烷生物碱

IF 1.3 4区 生物学 Q4 CHEMISTRY, MEDICINAL
Phytochemistry Letters Pub Date : 2024-07-26 DOI:10.1016/j.phytol.2024.07.009
Xiao-hui Sun , Wen-jian Gu , Tong-tong Min , Ya-mei Zhang , Pu-zhao Zhang
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引用次数: 0

摘要

从东方马兜铃全株中分离出两种新的孕烷生物碱，分别命名为 N,N-二甲基氨基-3α-三甲氨基-孕甾-5-烯（1）和 3α-N-甲基氨基-孕甾-5，14，16-三烯-20-酮（2）。通过解释光谱数据和对比文献，确定了它们的结构。化合物 1 和 2 对脂多糖（LPS）激活的 BV-2 小胶质细胞的 NO 生成有一定的抑制作用，IC50 值分别为 16.88 ± 0.10 和 24.26 ± 0.30 μM。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Two new pregnane alkaloids from Sarcococca orientalis

Two new pregnane alkaloids, named N,N-dimethylamino-3α-tigloylamino-pregn-5-ene (1) and 3α-N-methylamino-pregn-5, 14, 16-trien-20-one (2), were isolated from the whole plants of Sarcococca orientalis. Their structures were assigned by interpreting the spectroscopic data and comparing the literature. Compounds 1 and 2 exhibited a certain inhibitory effects on NO production in lipopolysaccharide (LPS)-activated BV-2 microglial cells with IC50 values of 16.88 ± 0.10 and 24.26 ± 0.30 μM, respectively.

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来源期刊
Phytochemistry Letters
Phytochemistry Letters 生物-生化与分子生物学
CiteScore
3.00
自引率
11.80%
发文量
190
审稿时长
34 days
期刊介绍： Phytochemistry Letters invites rapid communications on all aspects of natural product research including: • Structural elucidation of natural products • Analytical evaluation of herbal medicines • Clinical efficacy, safety and pharmacovigilance of herbal medicines • Natural product biosynthesis • Natural product synthesis and chemical modification • Natural product metabolism • Chemical ecology • Biotechnology • Bioassay-guided isolation • Pharmacognosy • Pharmacology of natural products • Metabolomics • Ethnobotany and traditional usage • Genetics of natural products Manuscripts that detail the isolation of just one new compound are not substantial enough to be sent out of review and are out of scope. Furthermore, where pharmacology has been performed on one new compound to increase the amount of novel data, the pharmacology must be substantial and/or related to the medicinal use of the producing organism.
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