SARS-CoV-2 蛋白 S 的伪环肽的合成及其与 COVID-19 患者具有诊断意义的抗体的相互作用

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-07-01 DOI:10.1016/j.mencom.2024.06.009

Ivan M. Ryzhov , Polina S. Obukhova , Oxana E. Galanina , Eugenia M. Rapoport , Natalia S. Egorova , Nicolai V. Bovin , Alexander B. Tuzikov

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引用次数: 0

摘要

本文提出了一种设计伪环状肽表位的方法：通过亲水性间隔物将脂质尾部连接到肽的 C 端和 N 端；由于有了两个脂质锚，共轭物可同时插入膜的两个部位，肽的构象也会受到限制。尽管存在两个长的脂质区域，但间隔物的高亲水性使整个结构具有水溶性，这对融入活细胞至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients

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Synthesis of pseudocyclic peptide of protein S of SARS-CoV-2 and its interaction with diagnostically significant antibodies of COVID-19 patients

An approach to the design of pseudocyclic peptide epitopes is proposed: lipid tails are attached to both C- and N-termini of the peptide through hydrophilic spacers; thanks to two lipid anchors, the conjugate is inserted into the membrane at two sites simultaneously, and the peptide becomes conformation- constrained. Despite the presence of two long lipid regions, the high hydrophilicity of the spacer makes the entire structure water-soluble, which is crucial for integration into living cells.

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.