环丙沙星药物在涉及 PVP10000 + Li2SO4 + 水的 ATPSs 中的液液平衡与分离：温度和 pH 值的影响

IF 2.1 3区工程技术 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Chemical & Engineering Data Pub Date : 2024-07-07 DOI:10.1021/acs.jced.4c0002710.1021/acs.jced.4c00027

Reza Azizi Adeh, Ebrahim Nemati-Kande* and Vahid Hosseinpour Hashemi,

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引用次数: 0

摘要

该研究考察了分子量为 10,000 g/mol 的聚乙烯吡咯烷酮和硫酸锂水溶液两相体系在不同温度和 pH 值条件下的液液平衡。此外，还探讨了温度和 pH 值对系统成相能力的影响。经验方程和热力学方程有效地模拟了所获得的实验二项式曲线和平分线组成。在温度为 298.15、308.15 和 318.15 K，pH 值为 4.0、6.0、7.0、8.0 和 10.0 的条件下，研究了环丙沙星药物在该体系中的分配情况。研究结果表明，在 308.15 K 和中性 pH 条件下，分配效果最佳。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Liquid–Liquid Equilibrium and Partitioning of Ciprofloxacin Drug in ATPSs Involve PVP10000 + Li2SO4 + Water: The Effect of Temperature and pH

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Liquid–Liquid Equilibrium and Partitioning of Ciprofloxacin Drug in ATPSs Involve PVP10000 + Li2SO4 + Water: The Effect of Temperature and pH

The liquid–liquid equilibrium of aqueous two-phase systems incorporating polyvinylpyrrolidone with a molecular weight of 10,000 g/mol and lithium sulfate was examined under various temperatures and pH conditions. The impact of temperature and pH on the system’s ability to form phases was also explored. The empirical and thermodynamic equations effectively modeled the obtained experimental binodal curves and tie-line compositions. Ciprofloxacin drug partitioning in this system was investigated at temperatures of 298.15, 308.15, and 318.15 K and pH levels of 4.0, 6.0, 7.0, 8.0, and 10.0. The findings revealed that optimal partitioning occurred at 308.15 K and neutral pH conditions.

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来源期刊

Journal of Chemical & Engineering Data 工程技术-工程：化工

CiteScore

5.20

自引率

19.20%

发文量

324

审稿时长

2.2 months

期刊介绍： The Journal of Chemical & Engineering Data is a monthly journal devoted to the publication of data obtained from both experiment and computation, which are viewed as complementary. It is the only American Chemical Society journal primarily concerned with articles containing data on the phase behavior and the physical, thermodynamic, and transport properties of well-defined materials, including complex mixtures of known compositions. While environmental and biological samples are of interest, their compositions must be known and reproducible. As a result, adsorption on natural product materials does not generally fit within the scope of Journal of Chemical & Engineering Data.