硫丹和六氯代苯与人体血清白蛋白的亲和力会影响普通人群的血清浓度

IF 5.3 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
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引用次数: 0

摘要

硫丹和六氯苯曾是广泛使用的有机氯农药。人们对人类接触硫丹和六氯苯的趋势以及硫丹和六氯苯在体内的迁移和分布情况给予了极大关注。我们测定了2012年至2016年间江苏省无锡市普通人群血清样本中硫丹I、硫丹II和六氯代苯的浓度。在整个研究期间,硫丹浓度变化不大,但六氯代苯浓度有所上升。超重者和吸烟者血清中的六氯苯浓度分别明显高于体重正常者(p = 0.028)和非吸烟者(p = 0.011)。六氯代苯会与人血清白蛋白(HSA)结合,并能在位点 II(子域 IIIA)与 CYS-461 和 ARG-484 形成卤素键。脂肪酸和尼古丁会增加六氯苯与 HSA 之间的亲和力,这也是超重者和吸烟者血清中六氯苯浓度分别高于正常体重者和非吸烟者的原因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population

Affinity of endosulfan and HCB with human serum albumin affects serum concentrations in a general population

Endosulfan and hexachlorobenzene (HCB) were previously widely used organochlorine pesticides. Much attention has been paid to trends in human exposure to endosulfan and HCB and to the transport and distribution of endosulfan and HCB within the body. We determined endosulfan I, endosulfan II, and HCB concentrations in serum samples collected from the general population of Wuxi in Jiangsu Province (China) between 2012 and 2016. The endosulfan concentrations varied little throughout the study period, but the HCB concentrations increased. The HCB concentrations were significantly higher in serum from overweight people and smokers than in serum from normal weight people (p = 0.028) and non-smokers (p = 0.011), respectively. HCB binds to human serum albumin (HSA) and can form halogen bonds to CYS-461 and ARG-484 at site II (subdomain IIIA). Fatty acids and nicotine increase the affinity between HCB and HSA, explaining the higher HCB concentrations in serum from overweight people and smokers than normal weight people and non-smokers, respectively.

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来源期刊
Emerging Contaminants
Emerging Contaminants Medicine-Public Health, Environmental and Occupational Health
CiteScore
10.00
自引率
6.70%
发文量
35
审稿时长
44 days
期刊介绍: Emerging Contaminants is an outlet for world-leading research addressing problems associated with environmental contamination caused by emerging contaminants and their solutions. Emerging contaminants are defined as chemicals that are not currently (or have been only recently) regulated and about which there exist concerns regarding their impact on human or ecological health. Examples of emerging contaminants include disinfection by-products, pharmaceutical and personal care products, persistent organic chemicals, and mercury etc. as well as their degradation products. We encourage papers addressing science that facilitates greater understanding of the nature, extent, and impacts of the presence of emerging contaminants in the environment; technology that exploits original principles to reduce and control their environmental presence; as well as the development, implementation and efficacy of national and international policies to protect human health and the environment from emerging contaminants.
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