用于光动力疗法和荧光诊断的纳米级酞菁铝系统以及 N-乙烯基吡咯烷酮与单甲基和二甲基丙烯酸酯的两性共聚物

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-07-01 DOI:10.1016/j.mencom.2024.06.007

Svetlana V. Kurmaz, Ivan V. Ulyanov, Nina S. Emelyanova, Vladimir A. Kurmaz, Alexey V. Kozlov, Lev R. Sizov, Alexander Yu. Rybkin

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引用次数: 0

摘要

酞菁铝是一种很有前途的光敏剂，可用于光动力疗法和荧光诊断。通过将其封装在 N-乙烯基吡咯烷酮与单甲基丙烯酸酯和二甲基丙烯酸酯的生物相容性共聚物中，获得了酞菁铝的水溶性纳米体系。研究人员测定了纳米颗粒在水溶液中的物理化学（水溶性、稳定性和尺寸）和光物理性质（吸收和荧光）。量子化学模型显示，染料的铝原子与所有单体单元的氧原子之间形成了配位键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nanosized systems of aluminum phthalocyanine and amphiphilic copolymers of N-vinylpyrrolidone with mono- and dimethacrylates for photodynamic therapy and fluorescence diagnostics

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Nanosized systems of aluminum phthalocyanine and amphiphilic copolymers of N-vinylpyrrolidone with mono- and dimethacrylates for photodynamic therapy and fluorescence diagnostics

Water-soluble nanosized systems of aluminum phthalo- cyanine, which is a promising photosensitizer for photodynamic therapy and fluorescence diagnostics, were obtained by encapsulating it in biocompatible copolymers of N-vinylpyrrolidone with mono- and dimethacrylates. The physicochemical (water solubility, stability and size of nanoparticles) and photophysical (absorption and fluorescence) properties of the resulting nanoparticles in aqueous solution were determined. Quantum chemical modeling revealed the formation of coordination bonds between the Al atom of the dye and the oxygen atoms of all monomer units.

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.